Log in to search using one of your social media accounts:

 

Heparin Cofactor II: A Novel Plausible Link of Obesity and Diabetes with Thrombosis.

Heparin Cofactor II: A Novel Plausible Link of Obesity and Diabetes with Thrombosis. J Atheroscler Thromb. 2017 Aug 10;: Authors: Hasegawa Y, Ishigaki Y PMID: 28794345 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Related Links:

Abstract Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate-containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs. IPPs and/or their metabolizing enzymes regulate various cell biological processes by modulating many proteins via diverse mechanisms. In the last decade, extensive research has been conducted in mammalian systems, particularly in knockout mouse models of relevant enzy...
Source: Biological Reviews of the Cambridge Philosophical Society - Category: Biology Authors: Tags: Biol Rev Camb Philos Soc Source Type: research
AbstractPurposeEnd-stage renal disease (ESRD) is associated with increased cardiovascular risk factors, electrolyte imbalances, and iron deficiency anemia. These factors may increase the risk of adverse outcomes in patients undergoing panniculectomy. There is a paucity of data regarding outcomes in patients with ESRD undergoing panniculectomy. The purpose of this study is to investigate whether ESRD is associated with increased rate of complications following a panniculectomy.MethodThe Nationwide Inpatient Sample database (2006 –2011) was used to identify patients who underwent a panniculectomy. Among this cohort, pa...
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by inflammation and oxidative stress, which contribute to the development of endothelial dysfunction (ED) in the same way as obesity. It is unknown how the increase in the percentage of body fat affects endothelial function (EF). Objectives: To determine how much the increase in the percentage of fat mass on the EF influences.Methods: A cross-sectional study, with stable patients aged>18 years with a diagnosis of COPD. Body composition was evaluated by electric biopimpedance by vector analysis (BIVA). Obesity was defined as>30% fat mass (FM) ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems COPD Source Type: research
Bariatric surgery is increasingly employed to improve fertility and reduce obesity related co-morbidities in obese women. Surgical weight loss not only improves the chance of conception but reduces the risk of pregnancy complications including pre-eclampsia, gestational diabetes, and macrosomia. However, bariatric procedures increase the incidence of intrauterine growth restriction (IUGR), fetal demise, thromboembolism and other gestational disorders. Using our rodent model of vertical sleeve gastrectomy (VSG), we tested the hypothesis that VSG in diet-induced, obese dams would cause immune and placental structural abnorma...
Source: Clinical Science - Category: Biomedical Science Authors: Tags: PublishAheadOfPrint Source Type: research
CONCLUSIONS: FLOT1 is a novel participant in the disposal of harmful C-TRLs via syndecan-1. Low expression of FLOT1 in T2DM liver may contribute to metabolic dyslipoproteinemia. PMID: 29162604 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
Perioperative hyperglycemia is an all too common issue (incidence 20‐40%) associated with significant surgical morbidity and mortality [1]. Often defined as a blood glucose>11.1mmol/L, peri‐operative hyperglycemia increases the risk for developing costly surgical site infections, sepsis, impairs wound healing, promotes endothelial dysfunction, thrombus formation, myocardial ischemia, stroke, neurocognitive dysfunction, prolongs length of hospitalization, and even death [2‐7].
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: LETTER TO THE EDITOR Source Type: research
Conclusion In patients undergoing SPL for the removal of adnexal masses in a gynecologic oncology practice, the rate of benign disease is high. SPL removal of adnexal masses is feasible and safe with favorable surgical outcomes, rare short-term adverse outcomes, and a low incisional hernia rate.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
We present evidence that, in addition to its improvement in glucose homeostasis and adiposity, PTP1B inhibition results in activation of aortic Akt and AMPKα1, that is independent of the effects on the IR itself. Most importantly, for the first time, we demonstrate that inhibition of PTP1B results in a decrease in circulating serum cholesterol and triglyceride levels and protection against atherosclerotic plaque formation. Atherosclerosis is now widely regarded as a chronic, low-grade inflammatory condition characterized by an increased pro-inflammatory environment and decreased anti-inflammation, pro-resoluti...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ABSTRACT Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds and fungi to mammals. Distinct classes of kinases generate different forms of energetic diphosphate‐containing IPPs from inositol phosphates (IPs). Conversely, polyphosphate phosphohydrolase enzymes dephosphorylate IPPs to regenerate the respective IPs. IPPs and/or their metabolizing enzymes regulate various cell biological processes by modulating many proteins via diverse mechanisms. In the last decade, extensive research has been conducted in mammalian systems, particularly in knockout mouse models of relevant enzymes. Re...
Source: Biological Reviews - Category: Biology Authors: Tags: Original Article Source Type: research
Abstract Cellulitis is a bacterial skin and soft tissue infection which occurs when the physical skin barrier, the immune system and/or the circulatory system are impaired. Diabetes, obesity and old age are associated with defects in all of these areas and as a result are major predisposing factors for cellulitis. In this review, we summarise current insights into the pathophysiology of cellulitis and place the Dutch guidelines on the clinical management of cellulitis of the lower extremities in perspective. Recent evidence on diagnostic strategies is discussed, the importance of which is underscored by findings t...
Source: The Netherlands Journal of Medicine - Category: General Medicine Authors: Tags: Neth J Med Source Type: research
More News: Cardiology | Diabetes | Eating Disorders & Weight Management | Endocrinology | Obesity | Thrombosis