rofecoxib, Vioxx

Title: rofecoxib, VioxxCategory: MedicationsCreated: 10/14/1999 12:00:00 AMLast Editorial Review: 8/8/2017 12:00:00 AM
Source: MedicineNet Arthritis General - Category: Rheumatology Source Type: news

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Abstract OBJECTIVE: The surgical management of tibial plateau fractures remains a challenge. The aim of surgery is the anatomical reconstruction of the joint surface with correct length, axis and rotation. The goal of osteosynthesis is to maintain a stable reduction to allow bone healing and functional aftercare. The continued advancements in 3D computed tomography has changed, the classification systems and, in parallel, the treatment strategies significantly changed. The 3‑column concept of Luo et al. has proven to be advantageous for planning of access, reduction and stabilisation. INDICATIONS:...
Source: Operative Orthopadie und Traumatologie - Category: Orthopaedics Authors: Tags: Oper Orthop Traumatol Source Type: research
This article discusses the most common tumor and tumor-like lesions arising at the shoulder. Osseous tumors of the shoulder rank second in incidence to those at the knee joint and include benign osteochondromas and myeloma or primary malignant lesions, such as osteosarcoma or chondrosarcomas. Soft tissue tumors are overwhelmingly benign, with lipomas predominating, although malignant lesions, such as liposarcomas, can occur. Numerous tumor-like lesions may arise from the joints or bursae, due to either underlying arthropathy and synovitis (eg, rheumatoid arthritis and amyloid) or related to conditions, including tenosynovi...
Source: Magnetic Resonance Imaging Clinics of North America - Category: Radiology Authors: Source Type: research
ObjectiveGenetic variants in the region of tumor necrosis factor –induced protein 3–interacting protein 1 (TNIP1) are associated with autoimmune disease and reducedTNIP1 gene expression. The aim of this study was to define the functional genetic mechanisms drivingTNIP1 hypomorphic expression imparted by the systemic lupus erythematosus –associatedTNIP1 H1 risk haplotype.MethodsDual luciferase expression and electrophoretic mobility shift assays were used to evaluate the allelic effects of 11 risk variants on enhancer function and nuclear protein binding in immune cell line models (Epstein ‐Barr virus [E...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
This study was undertaken to investigate the relationship of PPM1A to osteoclast differentiation by generating conditional gene‐knockout (PPM1Afl/fl;LysM ‐Cre) mice and evaluating their bone phenotype.MethodsThe bone phenotypes of LysM ‐Cre mice (n = 6) and PPM1Afl/fl;LysM ‐Cre mice (n = 6) were assessed by micro–computed tomography. Osteoclast differentiation was induced by culturing bone marrow–derived macrophages in the presence of RANKL and macrophage colony‐stimulating factor (M‐CSF), and was evaluated by counting tartrate‐resistant acid phosphatase– positive multinucleated cells. Level...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Publication date: Available online 29 March 2020Source: Joint Bone SpineAuthor(s): Olivia Berthoud, Guillaume Coiffier, Jean-David Albert, Anne Gougeon-Jolivet, Claire Goussault, Claude Bendavid, Pascal Guggenbhul
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Condition:   Psoriatic Arthritis Interventions:   Other: General evaluation;   Other: Dermatological evaluation;   Other: Rheumatological evaluation;   Other: para clinical data;   Other: Patient reported outcomes (PROs) Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Arthiritis in Children Intervention:   Other: Observation Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Psoriatic Arthritis Interventions:   Other: General evaluation;   Other: Dermatological evaluation;   Other: Rheumatological evaluation;   Other: para clinical data;   Other: Patient reported outcomes (PROs) Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Arthiritis in Children Intervention:   Other: Observation Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Our study suggested that quercetin suppresses the migration and invasion of FLSs via regulating the miR-146a/GATA6 axis. PMID: 32216502 [PubMed - as supplied by publisher]
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
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