Molecular Pathology of Bone Tumors: What Have We Learned and How Does It Affect Daily Practice?

Bone tumors are often found to be difficult by pathologists, because they are rare, and in total, almost 60 entities are recognized with considerable morphologic overlap. Similar to the classification of soft tissue tumors, the World Health Organization 2013 recognizes different categories: benign (n = 20), intermediate locally aggressive or rarely metastasizing (n = 10), and malignant (n = 28), and as such, the different bone tumor entities differ widely in treatment and outcome. In contrast to soft tissue tumors, immunohistochemistry is often of limited value, although in recent years some novel immunohistochemical markers have proven their value.

Source: Surgical Pathology Clinics - August 8, 2017 Category: Pathology Authors: Judith V.M.G. Bov ée Tags: Preface Source Type: research