Africa: African Countries Like Gambia Must Try New Strategies to End Malaria

[The Aspen Institute] Malaria is a monster. I was 12 years old the first time I contracted cerebral malaria. After several days of staying in bed unwell without receiving proper treatment from my boarding school dispensary, one night I woke up delirious, screaming and shouting. I had to be restrained by my brother and classmates. By the time I was rushed to a local hospital in Eastern Kenya, I was in a coma. While I survived, hundreds of thousands of people die from malaria each year.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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Abstract DHFR from Pf is a known target for malaria. There is a continued effort for the design and development of the potent inhibitor for PfDHFR in the control of malaria. Therefore it is of interest to screen PfDHFR with the derivatives of Pyrimethamine. The results show that the compound CID 10476801 has lowest docked energy (-11.48 kcal/mol) with protein likely to be a drug candidate, probably inhibiting PfDHFR structure. Residues of PfDHFR protein involved in the formation of hydrogen bonds with compound CID 10476801 are confirmed to be ASP54. The findings provide new insights into development of potent chem...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
This study investigated the prevalence of haplotypes of the Pfdhps, Pfdhfr, Pfcrt, Pfmdr1 and PfK13 resistance markers in isolates from asymptomatic patients from the Republic of the Congo following implementation of artemisinin based-combination therapy (ACT).MethodsPeripheral blood was collected from asymptomatic children in 2010 and 2015 from Brazzaville in the south and in 2013 in the north of the Congo. Genotypes of Pfmdr1, Pfcrt, Pfdhps, Pfdhfr and PfK13 were assessed by PCR.ResultsChildren from 2010 were younger than those from 2015 (mean age 5.38 years vs. 8.67 years; P = 0.003). The main Pfcrt haplotype ...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
150 years after Semmelweis advised fellow physicians to sanitize their hands to mitigate the effect of infections, the maintenance of hygiene is still a widespread problem in hospitals and the source of healthcare-associated infections. Now, technological solutions line up against microorganisms, bacteria, and fungi. Here are a few examples. 1 in 9 in-patients will die due to infection According to the US Center for Disease Control, studies show that on average, healthcare providers clean their hands less than half of the times they should. This significantly contributes to the spread of healthcare-associated infections (H...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Healthcare Design Medical Professionals Policy Makers clean digital digital health future HAI healthcare-associated infection hygiene Medicine robot robotics sensors technology trackers wearable Source Type: blogs
This study aimed to assess patients' knowledge of antimalarial treatment (ACT) and its association with patient adherence. A descriptive cross-sectional study design was employed in this study. Data were collected from April to May 2017. Both descriptive and inferential statistics in the form of frequencies, percentages, mean values, standard deviations, and Pearson's chi-square test were generated by use of Microsoft excel spreadsheet and IBM Statistical Package for Social Sciences (SPSS) version 23. The average age of the respondents surveyed for this study was 42.27 ± 11.09. Adherence level to ACT was 47%. The re...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
(University of Copenhagen The Faculty of Health and Medical Sciences) In a spectacular new study, researchers from the University of Copenhagen have discovered a method of diagnosing a broad range of cancers at their early stages by utilising a particular malaria protein, which sticks to cancer cells in blood samples. The researchers hope that this method can be used in cancer screenings in the near future.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Publication date: Available online 14 August 2018Source: Parasitology InternationalAuthor(s): Sofi Imtiyaz Ali, B. Gopalakrishnan, V. VenkatesaluAbstractVector-borne diseases transmitted by mosquitoes cause globally important diseases such as malaria, dengue fever, and filariasis. The incidence of these diseases can be reduced through mosquito control programs but these control programs currently rely on synthetic insecticides that can impact the environment, and has selected widespread mosquito resistance. Environment friendly and biodegradable natural insecticides discovered in plants offer an alternative approach to mos...
Source: Parasitology International - Category: Parasitology Source Type: research
Salary: Starting salary of £32,478 per annumContract type:Full-time, fixed-term for up to 2 yearsClosing date:11 September 2018Founded in 1898 and the oldest of its kind in the world, the Liverpool School of Tropical Medicine (LSTM) is an internationally recognised centre of excellence for teaching and research in tropical diseases.  LSTM’s Centre for Evidence Synthesis in Global Health has led developments in systematic reviews in tropical medicine and international health. In the 1990s, staff contributed to setting up Cochrane, and established the Cochrane Infectious Diseases Group (CIDG). This is now re...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Salary: Starting salary of £28,098 per annumContract type: Full-time, fixed-term for up to 2 yearsClosing date:11 September 2018 Founded in 1898 and the oldest of its kind in the world, the Liverpool School of Tropical Medicine (LSTM) is an internationally recognised centre of excellence for teaching and research in tropical diseases.  LSTM'S Centre for Evidence Synthesis in Global Health has led developments in systematic reviews in tropical medicine and international health. In the 1990s, staff contributed to setting up Cochrane and established the Cochrane Infectious Diseases Group (CIDG). This is now re...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
[The Exchange] Kenya -The costs of accessing malaria diagnosis and treatment services have largely reduced in the malaria endemic Lake region in Kenya since Community Health Workers (CHWs) started offering services in the communities.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Vivax malaria reemerged along the Demilitarized Zone (DMZ), Republic of Korea (ROK), in 1993. While it was hypothesized that vivax malaria would spread throughout the peninsula, nearly all cases were due to ex...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Case study Source Type: research
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