Stachaegyptin A-C: Neo-clerodane diterpenes from Stachys aegyptiaca

Publication date: September 2017 Source:Phytochemistry Letters, Volume 21 Author(s): M-E.F. Hegazy, Ahmed R. Hamed, El-Sayeda A. El-Kashoury, Alaa M. Shaheen, Wafaa A. Tawfik, Paul W. Paré, Essam Abdel-Sattar Phytochemical investigation of Stachys aegyptiaca resulted in the characterization of three new diterpenes (1-3) together with eleven known compounds including four neo-clerodane diterpenes and seven flavonoid aglycones. Structure elucidation was performed by spectroscopic analysis by HRFABMS, 1D and 2D NMR and X-ray. Isolated compounds were screened for anti-inflammatory activity using a lipopolysaccharide-induced nitric oxide inhibition assay employing murine macrophage cells. Among the assayed compounds, 13 (calycopterin) showed a concentration-dependent inhibition of LPS-induced nitric oxide release with a IC50 of 62.5μM. Graphical abstract

Source: Phytochemistry Letters - July 5, 2017 Category: Chemistry Source Type: research