The hidden world of drug interactions in anesthesia

This article dwells on the anesthetic drug interactions: pharmaceutical (mixing or not mixing), pharmacokinetic (alterations in distribution, metabolism, or clearance), pharmacodynamics (synergism, additive effect) and thermodynamic (affinity and intrinsic activity). The basic anesthetic triangle is a current concept and drug interactions are the cornerstone for safe anesthesia. These interactions are currently neglected and hence the anesthetist should recognize any drug interactions for a safer practice of anesthesia.
Source: Colombian Journal of Anesthesiology - Category: Anesthesiology Source Type: research

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Authors: Liu J, Yang L Abstract Effects of propofol and sevoflurane on blood glucose, hemodynamics, and inflammatory factors of patients with type 2 diabetes mellitus (T2DM) and gastric cancer (GC) were investigated. One hundred and ten patients with T2DM and GC, treated in The First Affiliated Hospital of Baotou Medical College (Baotou, China) from January 2017 to December 2018, were selected. Sixty patients anesthetized by propofol were included in the propofol group, whereas 50 patients anesthetized by sevoflurane were included in the sevoflurane group. The level of blood glucose, hemodynamic indicators, and inf...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
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Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
ConclusionResults from our study supported the idea that the release of mPFC and NAc exosomes of CCI model has elevated the pain sensations in the subjected mice. This study will further help in designing new clinical trials, and will revolutionize the drug-induced anesthetic responses.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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Source: - Category: Research Source Type: clinical trials
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Source: - Category: Research Source Type: clinical trials
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Source: - Category: Research Source Type: clinical trials
Condition:   Anxiety Interventions:   Device: RESPeRATE™;   Behavioral: Tell, Show and Do technique Sponsors:   Nourhan M.Aly;   Alexandria University Completed
Source: - Category: Research Source Type: clinical trials
Condition:   Hypotension on Induction Interventions:   Device: IVC Ultrasonography;   Device: Plethysmographic variability index (PVI) and perfusion index readings (PI) Sponsor:   Cairo University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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