A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein Emerging Microbes &Infections 6, e60 (June 2017). doi:10.1038/emi.2017.50 Authors: Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin &Wenjie Tan
Source: Emerging Microbes and Infections - Category: Infectious Diseases Authors: Source Type: research

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In this study, we compared the immunological efficacy of the vaccine candidates in BALB/c mice in terms of the levels of humoral and cellular immune responses. The results show that the rabies virus vector-based vaccine can induce remarkably earlier antibody response and higher levels of cellular immunity than the GEM particles vector. However, the GEM particles vector-based vaccine candidate can induce remarkably higher antibody response, even at a very low dose of 1 µg. These results indicate that vaccines constructed using different vaccine vector platforms for the same pathogen have different rates and trends...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In this study, a hybrid model has been designed by using stacked generalisation ensemble technique for prediction of linear B-cell epitopes. The goal of using stacked generalisation ensemble approach is to refine predictions of base classifiers and to get rid of the worse predictions. In this study, six machine learning models are fused to predict variable length epitopes (6–49 mers). The proposed ensemble model achieves 76.6% accuracy and average accuracy of repeated 10-fold cross-validation is 73.14%. The trained ensemble model has been tested on the benchmark dataset and compared with existing sequential B-cell ep...
Source: IET Systems Biology - Category: Biology Source Type: research
The Japanese Ministry of Health, Labour and Welfare, today informed the World Health Organization (WHO) of a confirmed case of a novel coronavirus (2019-nCoV) in a person who travelled to Wuhan, China. This is the second confirmed case of 2019-nCoV that has been detected outside of China, following confirmation of a case in Thailand on 13 January. Considering global travel patterns, additional cases in other countries are likely. Coronaviruses are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. ...
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Source: World Health Organization (WHO). Published: 1/15/2020. This one-page document, updated on January 15, 2020, summarizes World Health Organization (WHO) recommendations for surveillance of the novel coronavirus (nCoV) recently identified in Wuhan, China (2019-nCoV). WHO will update these recommendations as new information becomes available on the situation in Wuhan, China. This interim guidance was adapted from WHO ’s guidance materials published for Middle East respiratory syndrome coronavirus (MERS-CoV). (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Abstract Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe pulmonary infection, with ∼35% mortality. Spike glycoprotein (S) of MERS-CoV is a key target for vaccines and therapeutics because S mediates viral entry and membrane-fusion to host cells. Here, four different S subunit proteins, receptor-binding domain (RBD; 358-606 aa), S1 (1-751 aa), S2 (752-1296 aa), and SΔTM (1-1296 aa), were generated using the baculoviral system and immunized in mice to develop neutralizing antibodies. We developed 77 hybridomas and selected five neutralizing mAbs by immunization with SΔTM against...
Source: Virus Research - Category: Virology Authors: Tags: Virus Res Source Type: research
Source: World Health Organization (WHO). Published: 1/11/2020. This one-page document summarizes World Health Organization (WHO) recommendations for surveillance of the novel coronavirus (nCoV) recently identified in Wuhan, China (2019-nCoV). WHO will update these recommendations as new information becomes available on the situation in Wuhan, China. This interim guidance was adapted from WHO ’s guidance materials published for Middle East respiratory syndrome coronavirus (MERS-CoV). (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Some coronaviruses can cause colds, while others can trigger severe respiratory diseases such as SARS and MERS, the AP reported.
Source: WebMD Health - Category: Consumer Health News Source Type: news
A new coronavirus appears to be causing a pneumonia-like illness in China. It is certainly a zoonotic infection – jumping from non-human animals to humans – as exemplified by previous outbreaks of SARS and MERS coronaviruses. The government in Wuhan, China confirmed on 31 December that dozens of cases of pneumonia of unknown cause were […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Information coronavirus emerging virus MERS pneumonia respiratory disease SARS viral viruses Wuhan outbreak zoonosis Source Type: blogs
China ’s viral pneumonia outbreak may have jumped species barrier, raising fears of pandemicThe finding that the outbreak of viral pneumonia in China that has struck 59 peoplemay be caused by a coronavirus, the family of viruses behind Sars, which spread to 37 countries in 2003, causing global panic and killing more than 750 people, means that health authorities will be watching closely.China says the illness is not Sars (severe acute respiratory syndrome), nor Mers (Middle East respiratory syndrome), both of which are caused by coronaviruses, and so far it appears milder than both. Unlike Sars, it does not appear to...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Epidemics Infectious diseases Health China Sars Ebola Asia Pacific Society World news World Health Organization Science Medical research Microbiology Source Type: news
A cluster of more than 50 pneumonia cases in China's central city of Wuhan may be due to a newly emerging member of the family of viruses that caused the deadly SARS and MERS outbreaks, World Health Organization (WHO) said on Wednesday.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news
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