Non-Opioid Drug More Effective for Migraines: Study

MONDAY, June 19, 2017 -- The drug prochlorperazine is more effective than the opioid hydromorphone in treating emergency room patients with acute migraine, a new study reports. Acute migraine -- an intense, throbbing headache that may be...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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People with obsessive-compulsive disorder (OCD) who don ’t achieve adequate relief from medication and cognitive-behavioral therapy may benefit from deep transcranial magnetic stimulation (dTMS), astudy inAJP in Advancesuggests.During dTMS treatment, a cap containing coils delivers magnetic pulses to stimulate nerve cells in the brain. The study compared active dTMS treatment with sham (inactive) treatment in 87 people with OCD, with participants in the active treatment group experiencing greater improvement in symptoms at the end of treatment and at a follow-up assessment four weeks later.The study, led by Lior Carm...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance deep transcranial magnetic stimulation dTMS headache Lior Carmi obsessive-compulsive disorder OCD Yale-Brown Obsessive Compulsive Scale Source Type: research
Condition:   Migraine Interventions:   Drug: Lasmiditan;   Drug: Placebo Sponsor:   Eli Lilly and Company Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Episodic Migraine Interventions:   Drug: Galcanezumab;   Drug: Placebo Sponsor:   Eli Lilly and Company Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Kato Y, Hayashi T, Arai N, Tanahashi N, Takahashi K, Takao M Abstract Postural tachycardia syndrome (POTS) can cause orthostatic headache. However, it is difficult to differentiate POTS from spontaneous intracranial hypotension (SIH) caused by cerebrospinal fluid (CSF) leaks. We herein report a 53-year-old woman who presented with SIH associated with POTS. A cervicothoracic and lumbar epidural blood patch rapidly improved not only the headache but also the orthostatic tachycardia, suggesting POTS secondary to SIH. This case suggests that a CSF leak can cause secondary POTS. Therefore, POTS should be consid...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
The 'life-changing' injection has been approved for use in Scotland, but not yet in England.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
This study investigates whether METH induces autophagy in the human dopaminergic neuroblastoma cell line SH-SY5Y, then examines the neuroprotective effects of gastrodin against autophagy in METH-treated SH-SY5Y cells. The effects of METH on the protein expressions of autophagy-related genes (LC3B and Beclin-1) were evaluated with and without gastrodin. The presence of autophagosomes in the METH-induced treatment with and without gastrodin is revealed through transmission electron microscopy. Pharmacological intervention was employed to study the role of the AKT/mTOR signaling pathway in the gastrodin-mediated neuroprotecti...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
ConclusionOur findings suggest that this computer-based method is a valid instrument for assessing risks in the visual work environment. By incorporating subjective ratings by the worker as well as objective measurements of the work environment, it provides a good basis for recommendations with respect to daylight, lighting, work surfaces/material, and work object.Relevance to industryVisual environment factors, such as glare, can cause eyestrain, headache and musculoskeletal discomfort. This method satisfies the need of a valid tool for determining risks associated with the visual work environment. It contains both worker...
Source: International Journal of Industrial Ergonomics - Category: Occupational Health Source Type: research
Conclusion: The possible relationship between migraine and sensory processing disorder or difficulties stresses the need to screen for sensory processing difficulties among children with migraine and when found – refer to their impacts on children’s daily function and quality of life.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Cerebral amyloid angiopathy (CAA)-related inflammation (CAA-RI) is a rare CAA variant characterized by acute or subacute encephalopathy, headache, epilepsy, or focal neurological deficits. Radiologically, CAA-RI presents with widespread white matter lesions on brain magnetic resonance imaging in addition to the hemorrhagic imaging features of CAA. Previous studies have found that the apolipoprotein E (ApoE) ε4 allele and ε4/ε4 genotype were over-represented in CAA-RI. The role of the ApoE ε2 allele in CAA-RI, however, is largely unknown, partly due to the rarity of the ε2/ε2 ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
We present a 48-year-old woman presenting with an inflammatory meningitis-like syndrome with headache and neck stiffness. Lumbar puncture was normal and computed tomography (CT) of the atlantoaxial joint showed abnormal calcifications around the odontoid process, leading to a tentative diagnosis of crowned dens syndrome. In addition, signs of active inflammation in and around the dens were present on cervical MR imaging. Since CDS can mimic meningitis or giant-cell arteritis, neurologists should be aware of this entity. If CDS is suspected, the bone window on the head CT scan can lead to the diagnosis. On the other hand, a...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
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