Inference of Biochemical S-Systems via Mixed-Variable Multiobjective Evolutionary Optimization.

Inference of Biochemical S-Systems via Mixed-Variable Multiobjective Evolutionary Optimization.
Comput Math Methods Med. 2017;2017:3020326
Authors: Chen Y, Chen D, Zou X
Abstract
Inference of the biochemical systems (BSs) via experimental data is important for understanding how biochemical components in vivo interact with each other. However, it is not a trivial task because BSs usually function with complex and nonlinear dynamics. As a popular ordinary equation (ODE) model, the S-System describes the dynamical properties of BSs by incorporating the power rule of biochemical reactions but behaves as a challenge because it has a lot of parameters to be confirmed. This work is dedicated to proposing a general method for inference of S-Systems by experimental data, using a biobjective optimization (BOO) model and a specially mixed-variable multiobjective evolutionary algorithm (mv-MOEA). Regarding that BSs are sparse in common sense, we introduce binary variables indicating network connections to eliminate the difficulty of threshold presetting and take data fitting error and the L0-norm as two objectives to be minimized in the BOO model. Then, a selection procedure that automatically runs tradeoff between two objectives is employed to choose final inference results from the obtained nondominated solutions of the mv-MOEA. Inference results of the investigated networks demonstrate that our method can identify their dynamical properties w...

Source: Computational and Mathematical Methods in Medicine - June 15, 2017 Category: Statistics Tags: Comput Math Methods Med Source Type: research