Getting stress out of stressed-out stress granules

Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP-43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal, Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase transition of these stress granules from liquid to solid. This discovery provides a model connecting protein aggregation to stress granule dysfunction.

Source: EMBO Journal - June 14, 2017 Category: Molecular Biology Authors: Siwach, P., Kaganovich, D. Tags: Membrane & Intracellular Transport, Protein Biosynthesis & Quality Control, RNA Biology News [amp ] Views Source Type: research