An evolving arsenal: viral RNA detection by RIG-I-like receptors.

An evolving arsenal: viral RNA detection by RIG-I-like receptors.
Curr Opin Microbiol. 2014 Jun 6;20C:76-81
Authors: Fitzgerald ME, Rawling DC, Vela A, Pyle AM
Abstract
RIG-I-like receptors (RLRs) utilize a specialized, multi-domain architecture to detect and respond to invasion by a diverse set of viruses. Structural similarities among these receptors provide a general mechanism for double strand RNA recognition and signal transduction. However, each RLR has developed unique strategies for sensing the specific molecular determinants on subgroups of viral RNAs. As a means to circumvent the antiviral response, viruses escape RLR detection by degrading, or sequestering or modifying their RNA. Patterns of variation in RLR sequence reveal a continuous evolution of the protein domains that contribute to RNA recognition and signaling.
PMID: 24912143 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - June 6, 2014 Category: Microbiology Authors: Fitzgerald ME, Rawling DC, Vela A, Pyle AM Tags: Curr Opin Microbiol Source Type: research