StreAM-[Formula: see text]: algorithms for analyzing coarse grained RNA dynamics based on Markov models of connectivity-graphs.

CONCLUSIONS: The proposed algorithm performs well on large simulated as well as real world dynamic graphs. Additionally, StreAM-[Formula: see text] provides insights into nucleotide based RNA dynamics in comparison to conventional metrics like the root-mean square fluctuation. In the light of experimental data our results show important design opportunities for the riboswitch.
PMID: 28572834 [PubMed]

Source: Algorithms for Molecular Biology : AMB - June 3, 2017 Category: Molecular Biology Authors: Jager S, Schiller B, Babel P, Blumenroth M, Strufe T, Hamacher K Tags: Algorithms Mol Biol Source Type: research