Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior

This study provides new insight into the therapeutic benefit of combining NEDD9 depletion with ROCK inhibition to reduce tumor cell dissemination and discovers a new regulatory role of NEDD9 in the modulation of VAV2-dependent activation of Rac1 and actin polymerization. Mol Cancer Res; 15(6); 670–82. ©2017 AACR.

Source: Molecular Cancer Research - June 1, 2017 Category: Cancer & Oncology Authors: Jones, B. C., Kelley, L. C., Loskutov, Y. V., Marinak, K. M., Kozyreva, V. K., Smolkin, M. B., Pugacheva, E. N. Tags: Cell Death and Survival Source Type: research