Adult-onset blue rubber bleb nevus syndrome (BRBNS) associated with fatal stroke: Rare but important

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by vascular malformations on the skin and visceral organs. First described in 1860, there are only around 200 case reports in the literature. A typical cutaneous lesion is nipplelike and bluish that easily compresses and refills slowly. Extracutaneous lesions most frequently affect the gastrointestinal (GI) system, causing bleeding and chronic anemia. Besides the GI systems, it has also been shown to affect multiple organs, including the central nervous system (CNS).
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research