Hyperoxia provokes a time- and dose-dependent inflammatory response in mechanically ventilated mice, irrespective of tidal volumes

Mechanical ventilation and hyperoxia have the potential to independently promote lung injury and inflammation. Our purpose was to study both time- and dose-dependent effects of supplemental oxygen in an experi...

Source: Intensive Care Medicine Experimental - May 26, 2017 Category: Surgery Authors: Hendrik J. F. Helmerhorst, Laura R. A. Schouten, Gerry T. M. Wagenaar, Nicole P. Juffermans, Joris J. T. H. Roelofs, Marcus J. Schultz, Evert de Jonge and David J. van Westerloo Source Type: research