A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium

AbstractA new biphenyl ether derivative, 2-hydroxy-6-(2 ′-hydroxy-3′-hydroxymethyl-5-methylphenoxy)-benzoic acid (1), was isolated together with the known benzophenone derivative, monodictyphenone (2), from a culture broth of Indonesian ascidian-derivedPenicillium albobiverticillium TPU1432 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of1 was elucidated based on NMR experiments. Compound2 exhibited moderate inhibitory activities against protein tyrosine phosphatase (PTP) 1B, T cell PTP (TCPTP), and CD45 tyrosine phosphatase (CD45), whereas compound1 modestly inhibited CD45 activity.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research