C-geranylated flavanones from YingDe black tea and their antioxidant and α-glucosidase inhibition activities

Publication date: 15 November 2017 Source:Food Chemistry, Volume 235 Author(s): Hua Zhou, Hai-Mei Li, Yang-Min Du, Ri-An Yan, Shi-Yi Ou, Tian-Feng Chen, Yong Wang, Li-Xin Zhou, Liang Fu YingDe black tea is produced from crude tea prepared from leaves of Camellia sinensis var. assamica. In this work, we isolated and identified five novel flavanones, namely, amelliaone A–E (1–5), along with seven known compounds 6–12 from the ethanol extract of YingDe black tea. The structures of these five novel phenolic compounds were determined using extensive 1D and 2D nuclear magnetic resonance spectroscopy experiments. The compounds were further evaluated for antioxidant, α-glucosidase inhibitory, and cytotoxic activities. Compound 1 exhibited higher α-glucosidase inhibitory activity with a half-maximum inhibitory concentration value (IC50) of 10.2µM compared with acarbose (18.2µM).
Source: Food Chemistry - Category: Food Science Source Type: research