Eudesmanolide sesquiterpenes and protein tyrosine phosphatase 1B inhibitory ent-kaurene diterpenes from aerial parts of Indonesian Wedelia prostata

Publication date: June 2017 Source:Phytochemistry Letters, Volume 20 Author(s): Delfly B. Abdjul, Hiroyuki Yamazaki, Wilmar Maarisit, Fitje Losung, Henki Rotinsulu, Defny S. Wewengkang, Deiske A. Sumilat, Michio Namikoshi Seven eudesmanolide sesquiterpenes (1–7) and two ent-kaurene diterpenes (8 and 9) including two new (9R)-eudesman-9,12-olides, named wedelolides I and J (1 and 2), were isolated from the aerial parts of Indonesian Wedelia prostata. The structures of 1 and 2 were assigned based on their spectroscopic data. Diterpenes 8 and 9 inhibited the activity of protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 8.3 and 28μM, respectively. Among sesquiterpenes 1–7, compound 4, wedelolide D, exhibited 32% inhibitory activity against PTP1B at 20μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research