Biological basis for human capacitation —revisited

<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">BACKGROUND</div>A little more than a decade ago a review entitled ‘Biological basis for human capacitation’ was published. A primary conclusion of the review was that with all the technological advances that have been made since the first experiments demonstrated the<span style="font-style:italic;">in vivo</span> requirement of capacitation for fertilization, very little progress had since been made, most significantly for human.<div class="boxTitle">OBJECTIVE AND RATIONALE</div>The present review was carried out to provide an update on the biological basis for human capacitation. It briefly revisits the original schema, presents a review of the literature that urged research interest in human sperm capacitation and puts under the spotlight the original definition of capacitation balanced against the limitations of experiments<span style="font-style:italic;">in vitro</span> to characterize a complex process that necessarily mandates a female component, and very recent findings in the mouse. It also includes proposed considerations for new thinking regarding capacitation, and progress toward understanding the biology of human capacitation.<div class="boxTitle">SEARCH METHODS</div>The PubMed, Google Scholar and Scopus literature databases were reviewed extensively using inclusive, broad and multispecies search...
Source: Human Reproduction Update - Category: OBGYN Source Type: research