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We are pleased that Dr Ophir agrees with the importance of our retrospective analysis of pooled data from the DRCR.net Protocol I study1,2 and the need for the development of alternate approaches to diagnosis and treatment of diabetic macular edema (DME). In his letter, Dr Ophir re-emphasizes the modest gains received by many patients from intensive treatment and monitoring with ranibizumab plus prompt focal/grid laser treatment in the Protocol I study.2,3 In response to our statement that an effective treatment algorithm for DME is uncertain in this group of suboptimal responders, he offers a systematic evidence-based approach to diagnosis and treatment of diffuse diabetic macular edema (DDME) that relies on the choice of full-field 3D optical coherence tomography figures and video clips to accurately assess the most common tractional mechanisms of DDME, usually overlooked with the use of other imaging studies.

Source: American Journal of Ophthalmology - March 22, 2017 Category: Opthalmology Authors: Victor H. Gonzalez, Joanna Campbell, Nancy M. Holekamp, Szil árd Kiss, Anat Loewenstein, Albert J. Augustin, Julia Ma, Allen C. Ho, Vaishali Patel, Scott M. Whitcup, Pravin U. Dugel Tags: Correspondence Source Type: research