No correlation between mtDNA amount and methylation levels at the CpG island of POLG exon 2 in wild-type and mutant human differentiated cells
Conclusions
This study suggests that, at variance with mouse and un/de-differentiated human cells, differentiated human cells control mtDNA levels irrespective of POLG methylation. The factors which actually control the mtDNA levels in such cell types remain to be identified.
Source: Journal of Medical Genetics - Category: Genetics & Stem Cells Authors: Steffann, J., Pouliet, A., Adjal, H., Bole, C., Fourrage, C., Martinovic, J., Rolland-Galmiche, L., Rotig, A., Tores, F., Munnich, A., Bonnefont, J.-P. Tags: Epigenetics Source Type: research