The Role of Topical Timolol in the Treatment of Infantile Heman-giomas: A Systematic Review and Meta-analysis.

The Role of Topical Timolol in the Treatment of Infantile Heman-giomas: A Systematic Review and Meta-analysis. Acta Derm Venereol. 2017 Apr 19;: Authors: Khan M, Boyce A, Prieto-Merino D, Svensson Å, Wedgeworth E, Flohr C Abstract To date the efficacy and safety of topical timolol in the treatment of infantile hemangioma has not be reviewed and analysed systematically. We collated all published data on the efficacy and safety of topical timolol in the treatment of infantile hemangioma. A total of 31 studies with 691 patients were included. The fixed effects pooled estimate of the response rate defined as any improvement from baseline of infantile hemangioma after treatment with topical timolol was significant (RR = 8.96; 95% CI 5.07-15.47; heterogeneity test p = 0.99), and the treatment was overall well tolerated. However, the quality of evidence was low to moderate. Topical timolol is an effective treatment for small infantile hemangioma, with no significant adverse effects noted. However, there is still a need for adequately powered randomised controlled trials. PMID: 28421234 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research