Proposal of the existence of an inducible skin associated lymphoid tissue (iSALT) in the cutaneous lesion of secondary syphilis

The chronic immune response induces the infiltration of the target organs with lymphocytes, which organize themselves into distinct T and B cell zones. This phenomenon has been termed tertiary lymphoid organ (TLO) formation and is often found in the mucosa as the mucosa-associated lymphoid tissue (MALT). By analogy, Streile in introduced a concept of skin-associated lymphoid tissue (SALT) based on the findings that the skin harbors T cells and dendritic cells (DCs). Although the existence of SALT had been controversial, we have confirmed sequential clustering of DCs and T cells at the dermal post-capillary venule in murine contact hypersensitivity (CHS), a model of contact dermatitis.
Source: Journal of Dermatological Science - Category: Dermatology Authors: Tags: P10-14[O3-12] Source Type: research