In vitro head-to-head comparison between octreotide and pasireotide in GH-secreting pituitary adenomas.
Conclusions: Overall, OCT and PAS equally reduced GH secretion in vitro. Adenomas with lower sst2 mRNA expression and a lower sst2/sst5 mRNA ratio showed a better response to PAS compared to OCT (6/33, 18%). SSTR evaluation in GH-omas may become a tool for tailored SSA treatment in acromegaly patients.
PMID: 28323931 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Gatto F, Feelders RA, Franck SE, van Koetsveld PM, Dogan F, Kros JM, Neggers SJ, van der Lely AJ, Lamberts SW, Ferone D, Hofland LJ Tags: J Clin Endocrinol Metab Source Type: research
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