In vitro head-to-head comparison between octreotide and pasireotide in GH-secreting pituitary adenomas.

Conclusions: Overall, OCT and PAS equally reduced GH secretion in vitro. Adenomas with lower sst2 mRNA expression and a lower sst2/sst5 mRNA ratio showed a better response to PAS compared to OCT (6/33, 18%). SSTR evaluation in GH-omas may become a tool for tailored SSA treatment in acromegaly patients. PMID: 28323931 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research