3-D-printed bioabsorbable scaffold for ACL reconstruction with bone regeneration

(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers have designed a 3-D-printed porous scaffold for use in reconstructing ruptured anterior cruciate ligaments (ACL) in the knee and engineered it to deliver a human bone-promoting protein over an extended period of time to improve bone regeneration.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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ConclusionThis article reviews the regulations on graft tissue within the United States, factors affecting the biomechanics of allograft tissue, differences in allograft tissue choices, and the use of allograft for anterior cruciate ligament reconstruction and multiligamentous knee injury reconstruction.Level of evidenceV
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
AbstractPurposeTo compare the “all-inside technique” for anterior cruciate ligament (ACL) reconstruction using a short, quadrupled semitendinosus tendon (ST4) autograft and suspensory cortical fixation on both the femoral and tibial side vs the “conventional technique” using a semitendinosus/gracilis (ST/G) autograft fix ed with a suspensory device on the femoral side and with an interference screw on the tibial side, in terms of clinical and functional outcomes.MethodsA total of 90 patients were enrolled, randomised into two groups, and prospectively followed. Group A comprised 45 patients treated ...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Anatomic tunnel formation and remnant preservation are valuable aspects of anterior cruciate ligament (ACL) reconstruction. However, anatomic landmarks are difficult to observe during remnant-preserving ACL reconstruction (ACLR). The aims of this study were to evaluate the: 1) femoral tunnel location created with guidance from the apex of the deep cartilage margin (ADC) and footprint compared to anatomical reference; and 2) relationship between femoral tunnel location and outcomes of ACLR.
Source: The Knee - Category: Orthopaedics Authors: Source Type: research
AbstractPurposeThe purpose was to calculate the incidence of osteoarthritis in individuals following Anterior Cruciate Ligament Reconstruction (ACLR) in a large, national database and to examine the risk factors associated with OA development.MethodsA commercially available insurance database was queried to identify new diagnoses of knee OA in patients with ACLR. The cumulative incidence of knee OA diagnoses in patients after ACLR was calculated and stratified by time from reconstruction. Odds ratios were calculated using logistic regression to describe factors associated with a new OA diagnosis including age, sex, BMI, me...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Purpose Hop tests are widely used to quantify recovery from anterior cruciate ligament reconstruction (ACLR) surgery. However, there is evidence that simply measuring hop distance may not be indicative of the quality of movement or representative of potential limitations in hopping mechanics, particularly during landing. The first purpose of the present study was to compare hop distance and loading symmetry between ACLR athletes and healthy uninjured recreational athletes. The second was to determine the association between hop distance and loading symmetry. Methods Twenty-five ACLR patients and 30 healthy controls co...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Conclusion Associations between outcomes related to lesser mechanical loading during walking and greater T1ρ MRI ILR were found 6 months after ACLR. Although preliminary, our results suggest that underloading of the ACLR limb at 6 months after ACLR may be associated with lesser proteoglycan density in the ACLR limb compared with the uninjured limb.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
(American Orthopaedic Society for Sports Medicine) Anterior Cruciate Ligament (ACL) reconstruction patients often face bone and muscle loss immediately following the procedure. Researchers presenting their work today at the AOSSM/AANA Specialty Day note that combining blood flow restriction (BFR) therapy with traditional rehabilitation efforts may slow bone loss and reduce return to function time.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionEarly degenerative changes in medial articular cartilage were observed with T1 ρ mapping at 2 years after ACL reconstruction. Postoperative anterior-posterior laxity is correlated with an increase in T1ρ values in the posteromedial femur and tibia. An increase in T1ρ values in the central medial femoral condyle was associated with knee symptoms.Level of evidenceIII.
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
AbstractPurposeTo analyse patient-related risk factors for 2-year ACL revision after primary reconstruction. The hypothesis was that younger athletes would have a higher incidence of an early ACL revision.MethodsThis prospective cohort study was based on data from the Norwegian and Swedish National Knee Ligament Registries and included patients who underwent primary ACL reconstruction from 2004 to 2014. The primary end-point was the 2-year incidence of ACL revision. The impact of activity at the time of injury, patient sex, age, height, weight, BMI, and tobacco usage on the incidence of early ACL revision were described by...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
Condition:   Anterior Cruciate Ligament Injury Interventions:   Procedure: ACLR done at 0 degrees KFA;   Procedure: ACLR done at 30 degrees KFA Sponsors:   Women's College Hospital;   Arthroscopy Association of North America Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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