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RheumShorts: New Knees, Lupus Med Switches (CME/CE)

(MedPage Today) -- The news in rheumatology this week included reports on knee replacements in the Dominican Republic, outcomes with scleroderma overlap disease, and reasons for switching maintenance therapy in lupus.
Source: MedPage Today Geriatrics - Category: Geriatrics Source Type: news

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Conclusion: Silica can be associated with autoimmune diseases and this case brings the association with an autoimmune renal disease (vasculitis) in silicotic patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and Environmental Health Source Type: research
Conclusions: Tobacco smoking and maternal smoking are strong and independent risk factors for IPF.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
CONCLUSION: An attempt at explaining the possible link between these disorders and migraine is discussed at the end of the review. Several autoimmune alterations are shared by most autoimmune diseases and headache types. Endothelial dysfunction is the only alteration that is common among all these disorders. PMID: 29173190 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Pulmonary hypertension (PH) is a clinical syndrome that is subdivided into five groups per the World Health Organization (WHO) classification, based largely on hemodynamic and pathophysiologic criteria. WHO Group 1  PH, termed pulmonary arterial hypertension (PAH), is a clinically progressive disease that can eventually lead to right heart failure and death, and it is hemodynamically characterized by pre-capillary PH and increased pulmonary vascular resistance in the absence of elevated left ventricular filli ng pressures.
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Tags: Review article Source Type: research
Abstract Autoimmunity is a status that immune mechanisms react against self-structure. The immune mechanisms, including cellular and molecular elements have been developed to immune body against foreign invades. Multiple factors such as genetic and epigenetic background, hormonal status, microbiome, and other factors can cause launching the autoreactive responses, in which the immune tolerance breaks and immune mechanisms are against self-antigens. Apoptosis is one of the important mechanisms in maintaining the tolerance and eliminating the autoreactive lymphocyte clones. Due to survivin roles in apoptosis and pro...
Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research
Publication date: Available online 3 November 2017 Source:Autoimmunity Reviews Author(s): Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Micheal Lichtbroun, Howard Amital, Yehuda Shoenfeld Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous gr...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Brachio-cervical inflammatory myopathy (BCIM) is a unique clinicopathologic entity characterized by neck and upper extremity weakness with relative sparing of lower extremities and commonly associated with connective tissue diseases or myasthenia gravis and serum autoantibodies (e.g., antinuclear antibody [ANA], anti–double stranded DNA [dsDNA], and anti–acetylcholine receptor).1 Muscle pathology is distinctive, with prominent B-cell infiltrates and endomysial membrane attack complex (MAC; C5b-9) deposition. Despite the detailed original series, there have been no subsequent reports (besides abstracts2,3) demon...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Clinical/Scientific Notes Source Type: research
This study demonstrates an association betweenTNFSF4 polymorphisms and susceptibility for the development of NMOSD in the Chinese population.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
AbstractPurpose of ReviewThe study aimed to illustrate the cardiopulmonary findings of the following collagen vascular diseases on cross-sectional imaging: rheumatoid arthritis, scleroderma (progressive systemic sclerosis), systemic lupus erythematosus, the inflammatory myopathies (polymyositis/dermatomyositis), and Sj ögren’s syndrome.Recent FindingsAlthough collagen vascular diseases can affect any part of the body, interstitial lung disease and pulmonary hypertension are the two most important cardiopulmonary complications and are responsible for the majority of morbidity and mortality in this patient populat...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
r M Abstract A complex pathomechanism accounts systemic sclerosis as a form of collagenosis. A triad of vasculopathy, autoinflammation, and dysbalance of the fibroblast function can be seen as cause, as well as symptomatic appearance. Comparative with other collagenoses, e.g. Lupus erythematosus, vasculopathy, instead of autoinflammation, appears to be clinically important in systemic scleroderma. The fact that autoinflammation does not represent the major role in the maintenance of the disease is also evident by the lack of therapeutic effects of classical systemic immunosuppressants. Therapeutic approaches with ...
Source: Clinical Hemorheology and Microcirculation - Category: Hematology Authors: Tags: Clin Hemorheol Microcirc Source Type: research
More News: Dominican Republic Health | Geriatrics | Lupus | Rheumatology | Scleroderma