Characterization and regulated naproxen release of hydroxypropyl cyclosophoraose-pullulan microspheres

Publication date: 25 April 2017 Source:Journal of Industrial and Engineering Chemistry, Volume 48 Author(s): Jae Min Choi, Benel Lee, Daham Jeong, Kyeong Hui Park, Eun-Ji Choi, Yong-Joon Jeon, Someshwar D. Dindulkar, Eunae Cho, Sun Hee Do, Kyungho Lee, Im-Soon Lee, Seyeon Park, Bong-Hyun Jun, Jae-Hyuk Yu, Seunho Jung Hydroxypropyl cyclosophoraose-pullulan (HPCys-Pul) microspheres were designed as a novel hybrid system of biocompatible pullulan matrice and pendant hydroxypropyl cyclosophoraoses with drug complexing ability. The HPCys-Pul microspheres were prepared by emulsion crosslinking method, and characterized using thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and solid state NMR spectroscopy. By virtue of hydroxypropyl cyclosophoraoses, the developed microspheres can encapsulate 4.2-fold more naproxen than pullulan microspheres. Korsmeyer–Peppas model was introduced for describing release kinetics. In vivo naproxen release analysis was carried out in Sprague-Dawley (SD) rats. From those results HPCys-Pul microsphere will be a promising platform for controlled drug delivery. Graphical abstract

Source: Journal of Industrial and Engineering Chemistry - February 19, 2017 Category: Chemistry Source Type: research