Reoperation May Be Effective for Some Patients With Zollinger-Ellison Syndrome Reoperation May Be Effective for Some Patients With Zollinger-Ellison Syndrome
As many as 25% of patients with persistent or recurrent Zollinger-Ellison syndrome (ZES) can be cured with repeat surgery, a prospective database study suggests.Reuters Health Information
A 63-year-old male patient presented to a secondary hospital suffering from severe epigastric pain, vomiting, and mild diarrhea for the last few hours. He said that he had experienced increasing fatigue and loss of appetite for many months prior. Furthermore, recurring mild epigastric pain persisted for many years. A gastroscopy in the ambulatory setting was unremarkable. These gastrointestinal symptoms had improved with proton pump inhibitor (PPI) therapy but recurred after discontinuation. Medical history revealed a diagnosis of arterial hypertension treated with lisinopril 20 mg and hydrochlorothiazide 25 mg, each once daily.
A 63-year-old male patient presented to a secondary hospital suffering from severe epigastric pain, vomiting and mild diarrhea for the last few hours. Since many months he experienced increasing fatigue and loss of appetite. Furthermore, recurring mild epigastric pain persisted since many years. A gastroscopy in the ambulatory setting has been unremarkable. These gastrointestinal symptoms had improved under proton-pump-inhibitor (PPI) therapy but recurred after discontinuation. Medical history revealed a diagnosis of arterial hypertension treated with lisinopril 20mg and hydrochlorothiazide 25mg, each once daily.
PMID: 32106911 [PubMed - in process]
In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome. PMID: 31832379 [PubMed]
Authors: Zimmer V, Glanemann M, Lammert F PMID: 31818929 [PubMed - in process]
In conclusion, our data suggest the strongest gastrin response evoked by SACI indicates the definitive location in patients with gastrinomas. In contrast, SACI could not accurately locate multiple gastrin-secreting lesions due to poor specificity. PMID: 31813923 [PubMed - as supplied by publisher]
This article aims to highlight his professional achievements. MATERIAL AND METHOD: We searched archives and reference databases for information on Roar Strøm. RESULTS: Roar Strøm grew up in Oslo, where he graduated with a medical degree in 1926, at just 23 years of age. Strøm pursued a focused career in surgery: specialist in surgery in 1935, medical doctorate in 1942, and senior consultant in surgery at Rogaland Hospital in Stavanger over the period 1945-1956. While in Stavanger, he published the extensive case history in Acta Chirurgica Scandinavica. The patient had a multi-year medical his...
Zollinger-Ellison syndrome (ZES) is a rare condition characterized by hypersecretion of gastrin by gastrinoma tumors leading to severe peptic ulcer disease with potential development of gastric carcinoid tumor...
ConclusionsWe concluded that in this setting of patients, with an age>70 and a WD NEN in progression to standard doses of SSA, HD-SSA represents a safe and effective second line therapy with a median PFS of 20.80 months.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Publication date: Available online 31 August 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Max B. Albers, Jerena Manoharan, Detlef K. BartschAbstractAbout 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymphat...