This Week in Science Vitamin B3 protects mice from glaucoma

Author: Priscilla Kelly
Source: ScienceNOW - Category: Science Authors: Tags: Glaucoma Source Type: news

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Condition:   Glaucoma, Open-Angle Interventions:   Dietary Supplement: 10 mg Lutein, 2 mg zeaxanthin, 10 mg meso-zeaxanthin;   Other: Placebo Sponsor:   Centre for Eye Research Ireland Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Trivli A, Zervou MI, Goulielmos GN, Spandidos DA, Detorakis ET Abstract Glaucoma is a group of progressive optic neuropathies that have in common characteristic optic nerve head changes, loss of retinal ganglion cells and visual field defects. Among the large family of glaucomas, primary open‑angle glaucoma (POAG) is the most common type, a complex and heterogeneous disorder with environmental and genetic factors contributing to its pathogenesis. Approximately 5% of POAG is currently attributed to single‑gene or Mendelian forms of glaucoma. Genetic linkage analysis and genome‑wide association studies...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
miR‑200c‑3p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting PTEN. Mol Med Rep. 2020 Jun 01;: Authors: Shen Y, Zhu Y, Rong F Abstract Glaucoma is an optic neuropathy that may lead to visual field loss and blindness. Human trabecular meshwork (HTM) cell dysfunction increases intraocular pressure, which leads to glaucoma. microRNAs (miRs) are single‑stranded non‑coding RNAs that regulate cellular processes in HTM cells. The aim of the present study was to evaluate the role of miR‑200c‑3p in HTM cells. HTM cells were treated with 300 µM H2O2,...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
[Uveitic glaucoma in Behçet's disease: When everything gets complicated]. J Fr Ophtalmol. 2020 Jul 01;: Authors: Belkhadir K, Boutimzine N, Tachfouti S, Laghmari M, Amazouzi A, Cherkaoui O Abstract INTRODUCTION: Behçet's disease is a systemic disease of unknown etiology. Its ocular manifestations are multiple and polymorphic, with uveitis at the top of the list. Classically, uveitis in Behçet's disease does not cause elevation of intraocular pressure. However, this may be found in 10 to 20% of cases, secondary to trabeculitis, trabecular obstruction by inflammatory cells, anterior ...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
AbstractPurposeTo explore the alterations of spontaneous neuronal activity and functional connectivity pattern using fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC) in patients with primary angle-closure glaucoma (PACG) and fALFF relationship with the glaucoma clinical indices.Materials and methodsForty-two PACG patients and 21 normal controls were enrolled in this study. Resting-state functional magnetic resonance imaging was firstly analyzed by fALFF and brain regions with altered fALFF between groups were selected as seeds for the further FC analysis. The relationships between ...
Source: Neurological Sciences - Category: Neurology Source Type: research
AbstractPurposeTo investigate outcomes associated with Baerveldt glaucoma drainage implant (BGI) surgery for refractory glaucoma secondary to transthyretin (TTR)-related familial amyloid polyneuropathy (FAP) with TTR Val30Met mutation.Study designRetrospective case series.MethodsMedical records of 5 eyes of 4 patients were reviewed. All patients had refractory glaucoma secondary to FAP with a history of unsuccessful intraocular pressure (IOP) control by trabeculectomy with mitomycin C, underwent BGI surgery, and were followed up for at least 1  year. The primary outcome was mean postoperative IOP, and secondary outcom...
Source: Japanese Journal of Ophthalmology - Category: Opthalmology Source Type: research
CONCLUSION: No statistically significant glaucoma risks were observed for the rs1800795 except rs1524107 polymorphism of IL-6. Further studies with a larger sample size are required to validate the effects of IL-6 polymorphisms on glaucoma risk. PMID: 32628041 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Eur J Ophthalmol Source Type: research
Authors: Konopińska J, Mariak Z, Rękas M Abstract Research on the methods used to achieve persistent and safe control of intraocular pressure resulted in the implementation of novel surgical procedures, such as canaloplasty and phacocanaloplasty. Herein, we review the literature focused on the safety profile of canaloplasty and phacocanaloplasty and the management of related complications. The aim of canaloplasty is to restore the natural aqueous outflow. This goal is achieved via a surgical procedure that involves viscocanalostomy with catheterisation of Schlemm's canal (360°) and placement of a circumferent...
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Publication date: Available online 3 July 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Sven Schnichels, José Hurst, Jan Willem de Vries, Sami Ullah, Agnieszka Gruszka, Minseok Kwak, Marina Löscher, Sascha Dammeier, Karl-Ulrich Bartz-Schmidt, Martin S Spitzer, Andreas Herrmann
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Contributors : Heather K Mak ; Jasmine S Yung ; Robert N Weinreb ; Shuk Han Ng ; Xu Cao ; Tracy Y Ho ; Tsz Kin Ng ; Wai Kit Chu ; Wing-Ho Yung ; Kwong Wai Choy ; Chi-Chiu Wang ; Tin-Lap Lee ; Christopher K LeungSeries Type : Non-coding RNA profiling by arrayOrganism : Rattus norvegicusIrreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration after optic nerve injury, mechanisms contributing to the age-related decline in axon regenerative...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Rattus norvegicus Source Type: research
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