[Comment] Can natalizumab be beneficial in acute ischaemic stroke?

Experimental and clinical evidence suggests an early activation of the immune system after brain ischaemia, with rapid invasion of ischaemic regions by leucocytes and an increase in complement concentrations in blood.1 –3 Natalizumab is a humanised monoclonal antibody against α4 integrin, a glycoprotein that is expressed on the surface of lymphocytes and monocytes and facilitates their adhesion to the endothelial vessel wall; natalizumab was approved for use as monotherapy in relapsing-remitting multiple sclero sis over a decade ago.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Comment Source Type: research