Filling in the gaps: estimating numbers of chlamydia tests and diagnoses by age group and sex before and during the implementation of the English National Screening Programme, 2000 to 2012.

Filling in the gaps: estimating numbers of chlamydia tests and diagnoses by age group and sex before and during the implementation of the English National Screening Programme, 2000 to 2012. Euro Surveill. 2017 Feb 02;22(5): Authors: Chandra NL, Soldan K, Dangerfield C, Sile B, Duffell S, Talebi A, Choi YH, Hughes G, Woodhall SC Abstract To inform mathematical modelling of the impact of chlamydia screening in England since 2000, a complete picture of chlamydia testing is needed. Monitoring and surveillance systems evolved between 2000 and 2012. Since 2012, data on publicly funded chlamydia tests and diagnoses have been collected nationally. However, gaps exist for earlier years. We collated available data on chlamydia testing and diagnosis rates among 15-44-year-olds by sex and age group for 2000-2012. Where data were unavailable, we applied data- and evidence-based assumptions to construct plausible minimum and maximum estimates and set bounds on uncertainty. There was a large range between estimates in years when datasets were less comprehensive (2000-2008); smaller ranges were seen hereafter. In 15-19-year-old women in 2000, the estimated diagnosis rate ranged between 891 and 2,489 diagnoses per 100,000 persons. Testing and diagnosis rates increased between 2000 and 2012 in women and men across all age groups using minimum or maximum estimates, with greatest increases seen among 15-24-year-olds. Our dataset can be used to parameterise and validate math...
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research

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Publication date: Available online 14 November 2019Source: Veterinary MicrobiologyAuthor(s): K. Laroucau, R. Aaziz, A. Lécu, S. Laidebeure, O. Marquis, F. Vorimore, S. Thierry, A. Briend-Marchal, J. Miclard, A. Izembart, N. Borel, L. RedonAbstractFollowing the occurrence of sudden death cases in a zoo reptile collection, histological analyses conducted on tissues from two common adders suggested an infection due to Chlamydia. The survey was extended to 22 individual snakes from the same collection and a PCR analysis targeting a conserved gene in Chlamydiaceae revealed bacterial shedding in six of them. The infection...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study, we evaluated a novel multiplex real-time PCR melting curve assay method for the simultaneous detection of 9 STD pathogens, including Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum, and herpes simplex virus.Methods: The analytical performance of the method, including its limit of detection (LOD), specificity, repeatability, and effect on different DNA extraction kits were evaluated. Additionally, we obtained 1,328 clinical specimens from 3 hospitals to detect the 9 STD pathogens using multiplex real-time...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
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Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
le EC Abstract Despite being in the midst of a global pandemic of infections caused by the pathogen Chlamydia trachomatis, a vaccine capable of inducing protective immunity remains elusive. Given the C. trachomatis mucosal port of entry, a formulation compatible with mucosal administration and capable of eliciting potent genital tract immunity is highly desirable. While subunit vaccines are considered safer and better tolerated, these are typically poorly immunogenic and require co-formulation with immune-potentiating adjuvants. However, of the adjuvants licensed for use in humans, very few drive robust cellular r...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
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Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
by Gertrud U. Rey Australian koalas are currently being invaded by koala retrovirus A (KoRV-A), a virus that causes an AIDS-like immunodeficiency and makes infected koalas more susceptible to cancers and opportunistic infections such as chlamydia. Retroviruses owe their name to their replication cycle, because their RNA genomes are reverse transcribed into DNA which is […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Gertrud Rey Information genome integration koala retrovirus KOR-A piRNA piwi protein retrotransposon rna silencing unspliced RNA viral viruses Source Type: blogs
(Umea University) Researchers at Ume å University (Sweden), in collaboration with researchers at the University of Maryland and Duke University (USA), now for the first time successfully performed targeted gene mutation in the zoonotic pathogen Chlamydia caviae.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In this study, an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics analysis was performed to identify differentially expressed proteins between TC0668 wild-type (TC0668wt) and TC0668 mutant (TC0668mut) strains at 6, 12, 18, and 24 h post-infection (p.i.). Of the 550 proteins differentially expressed at 18 h p.i., 222 and 328 were up-regulated and down-regulated, respectively, inTC0668mut-infected cells. The expression of seven up-regulated proteins (encoded by SRPRB, JAK1, PMM1, HLA-DQB1, THBS1, ITPR1, and BCAP31) and three down-regulated proteins (encoded by MAPKAPK2, TRAFD1, and ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract Given the high burden of HIV and other sexually transmitted infections (STIs) among female sex workers (FSW) and their potential role in bridging HIV/STIs into the general population, estimating the prevalence of HIV/STIs among FSW is essential for future research and policy developments. This systematic review and meta-analysis synthesize the available HIV/STIs data among FSW in Iran. We searched MEDLINE, PsycINFO, CINAHL, Embase, Web of Science, Google Scholar, and Iranian databases from inception through to January 2018. Inclusion criteria were original quantitative studies that measured HIV/STIs preva...
Source: Archives of Sexual Behavior - Category: Psychiatry & Psychology Authors: Tags: Arch Sex Behav Source Type: research
Condition:   Early Pregnancy Intervention:   Diagnostic Test: cervicovaginal culture and qPCR and serum qPCR Sponsor:   Fayoum University Hospital Recruiting
Source: - Category: Research Source Type: clinical trials
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