Characterization of ADME gene variation in 21 populations by exome sequencing

Conclusion: Exome sequencing was effective in accurately genotyping most ADME variants important for pharmacogenetic research, in addition to identifying rare or potentially de novo coding variants that may be clinically meaningful. Furthermore, as a class, ADME genes are more variable and less sensitive to purifying selection than non-ADME genes.

Source: Pharmacogenetics and Genomics - February 2, 2017 Category: Genetics & Stem Cells Tags: Original Articles Source Type: research