Repurposed Drugs May Treat Chikungunya Symptoms Repurposed Drugs May Treat Chikungunya Symptoms

Established autoimmune drugs that target T cells appeared to reduce virus-induced joint pathology, including inflammation in mouse models.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Related Links:

Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Abstract The northeastern region of Brazil has faced in the last 2 years the largest outbreak of chikungunya virus (CHIKV) infection in its history. There are still few studies on kidney involvement in CHIKV. The aim of this study is to describe the impact of chronic kidney disease (CKD) on CHIKV clinical manifestations and outcome. This is a cross-sectional study conducted in the State of Ceara, northeastern Brazil, including all registered cases of CHIKV infection in the period from January 2016 to December 2017. Clinical manifestations were collected from the notification reports from official data bank from th...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Conclusion: When the manifestations of CHIK become chronic and, the longer they last, more complications arise. Polyarthralgia can be immaterial, distancing individuals from their daily-life activities. Anti-inflammatory drugs (either steroid or not), in addition to immunosuppressants, homeopathy and physiotherapy are measures of treatment that, according to the literature, have been successful in relieving or extinguishing symptoms. However, it is fundamental that studies of CHIK treatment be further developed.Resumo Introdu ção: A chikungunya é uma arbovirose tropical, transmitida pela fêmea do...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
AbstractBackgroundChikungunya fever is a globally spreading mosquito-borne disease that shows an unexpected neurovirulence. Even though the neurological complications have been a major cause of intensive care unit admission and death, to date, there is no systematic analysis of their spectrum available.ObjectiveTo review evidence of neurological manifestations in Chikungunya fever and map their epidemiology, clinical spectrum, pathomechanisms, diagnostics, therapies and outcomes.MethodsCase report and systematic review of the literature followed established guidelines. All cases found were assessed using a 5-step clinical ...
Source: Neurocritical Care - Category: Neurology Source Type: research
The objective of this study was to assess the mortality associated with chikungunya epidemics in Brazil by comparing the mortality of pre-chikungunya with mortality during chikungunya epidemics2,3. Methods We studied the 3 Brazilian states with higher chikungunya incidence rates (IR), Pernambuco (9,410,772 inhabitants), Rio Grande do Norte (3,474,998 inhabitants), and Bahia (15,498,733 inhabitants)5. Bahia is the largest and most populated state, with a heterogeneous incidence of chikungunya, and therefore we analyzed separately each one of 9 administrative regions of Bahia. We retrospectively analyzed anonymous, publicly...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
Purpose of review: Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. Fever, rash and severe arthralgia are the hallmarks of chikungunya fever (CHIKF), the disease caused by this virus. The acute course of the disease usually lasts few weeks to months. Chronic, relapsing or persistent arthralgia and arthritis have been described mimicking rheumatoid arthritis (RA), requiring immunosuppressive drugs. The purpose of this review is to characterize both the chronic clinical course of CHIKF-associated arthritis and the immunological pathogenic mechanisms involved. Recent findings: The effect of postepidemic chronic per...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: INFECTIONS AND ENVIRONMENTAL ASPECTS OF AUTOIMMUNITY: Edited by Yehuda Shoenfeld Source Type: research
Conclusions:This case highlights the role of humoral immunity in early diagnosis and clearing WNV infection, as well as the importance of RT-PCR and NGS testing in patients with impaired B-cell immunity. NGS allowed for rapid confirmation and WNV load quantification in this patient. The early use of NGS for detection of infectious disease has clinical and economic relevance, especially in immunocompromised patients.Disclosure: Dr. Patel has nothing to disclose. Dr. Piquet has nothing to disclose. Dr. Schlaberg holds stock and/or stock options in IDbyDNA, which sponsored research in which Dr. Schlaberg was involved as an in...
Source: Neurology - Category: Neurology Authors: Tags: Zika, Chikungunya, West Nile Virus, and Other Viral Infections II Source Type: research
ABSTRACT Arboviruses have been emerging in different parts of the world due to genetic changes in the virus, alteration of the host and vector population dynamics, or because of anthropogenic environmental factors. These viruses ’ capacity for adaptation is notable, as well as the likelihood of their emergence and establishment in new geographic areas. In Brazilian epidemiologic scenario, the most common arboviruses are DENV, CHIKV, and ZIKV, although others may spread in the country. Little is yet known of the impact of viral co-circulation, which would theoretically result in more intense viremia or other immunolog...
Source: Revista de Saude Publica - Category: Global & Universal Source Type: research
;ka R Abstract The Zika virus is a flavivirus spread by mosquitoes. Its primary vectors are the Aedes aegypti and the Aedes albopictus. Before 2007 it sporadically caused benign morbidity. Since 2015, it started spreading "explosively" in America, especially in Brazil. In August 2016 they reported cases from New York and Poland, too. Most of the infections don't produce any symptoms, but can cause grave complications. The most important lesion is microcephalia that forms in fetuses. Microcephalia's most serious consequence is mental retardation, which puts great burden on both the family and the society....
Source: Orvosi Hetilap - Category: Journals (General) Authors: Tags: Orv Hetil Source Type: research
CONCLUSION: While there is an association between initial CHIKV infection and acute disease, a causal relationship with development of chronic arthralgia has not been established at this time. Potential causes of chronic CHIKV-induced arthritis have been postulated, including viral persistence, induction of autoimmune disease, and exacerbation of pre-existing joint disease. While there are numerous reports of chronic CHIKV-associated arthralgia and/or arthritis, there is currently no evidence of a definitive link between initial infection and development of chronic disease. Additional, prospective clinical research on CHIK...
Source: Open Rheumatology Journal - Category: Rheumatology Tags: Open Rheumatol J Source Type: research
More News: Autoimmune Disease | Chikungunya | Health | Infectious Diseases | Pathology