Stereotactic body radiation therapy and oligometastases.

[Stereotactic body radiation therapy and oligometastases.] Cancer Radiother. 2014 Apr 30; Authors: Bourgier C, Azria D, Fenoglietto P, Riou O, Almaghrabi MY, Supiot S, Mornex F, Giraud P Abstract In stage IV cancers, locoregional management of primitive tumours as surgery and/or radiotherapy improved both progression-free survival and overall survival. Among metastatic cancer patients, some of them are considered as oligometastatic stage as they present few metastatic sites associated with low tumor aggressiveness. For those patients, metastatic local control, and therefore prolonged time to progression should be reached through local treatments as surgery and/or radiofrequency ablation and/or stereotactic radiotherapy. Here we propose a review of oligometastatic stage and results from extracranial stereotactic radiotherapy in terms of efficacy and tolerance. PMID: 24792996 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research

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J Appl Clin Med Phys. 2021 Aug 2. doi: 10.1002/acm2.13353. Online ahead of print.ABSTRACTPURPOSE: The purpose of this study was to compare the dose-volume parameters and regression scatter plots of the iteratively improved RapidPlan (RP) models, specific knowledge-based planning (KBP) models, in volumetric-modulated arc therapy (VMAT) for prostate cancer over three periods.METHODS: A RP1 model was created from 47 clinical intensity-modulated radiation therapy (IMRT)/VMAT plans. A RP2 model was created to exceed dosimetric goals which set as the mean values +1SD of the dose-volume parameters of RP1 (50 consecutive new clini...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Source Type: research
The objective was to examine the effectiveness of the updated approach.METHODS: With IRB approval, outpatients with cancer were enrolled from January to December 2018. Assessments were recorded at baseline and three consecutive visits (BL, FU1, FU2, and FU3), including Numerical Rating Scale (NRS), the Brief Pain Inventory (BPI), the Edmonton Symptom Assessment System (ESAS), side effects, and analgesic use. The primary outcome was a favorable response, defined as an NRS decrease more than 30% or NRS
Source: Pain Research and Management - Category: Anesthesiology Authors: Source Type: research
Mike Sathekge Prostate cancer (PCa) causes significant morbidity and mortality in men globally. While localized PCa may be managed with curative intent by surgery and/or radiation therapy, the management of advanced hormone resistant metastatic disease (mCRPC) is more challenging. Theranostics is a principle based on the ability to use an organ specific ligand and label it to both a diagnostic and a therapeutic agent. The overexpression of prostate specific membrane antigen (PSMA) on prostate cancer cells creates a unique opportunity for development of targeted radionuclide therapy. The use of both beta and alpha emitt...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
ConclusionsWP-SIB-IMRT for LAPCa was safe over long-term observation, although no clear benefit of WPRT was observed among our small and highly selected cohort. Regarding the additional efficacy of WPRT, further investigations are needed.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
This article reviews the existing regulatory framework in which cancer drugs may be developed for use in combination with radiation therapy from the perspective of the US Food and Drug Administration (FDA).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
This study aimed to evaluate clinical outcomes and the toxicity of intensity-modulated radiation therapy with simultaneous integrated boost (SIB-IMRT) combined with androgen-deprivation therapy for clinically node-positive (cN1) prostate cancer. We retrospectively analyzed 97 patients with cN1 prostate cancer who received SIB-IMRT between June 2008 and October 2017 at our hospital. The prescribed dosages delivered to the prostate and seminal vesicle, elective node area, and residual lymph nodes were 69, 54, and 60 Gy in 30 fractions, respectively. Kaplan–Meier analysis was used to determine 5-year biochemical relapse...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionPrimary axillary breast carcinoma is a rare entity. Despite the paucity of literature, our findings and authors ’ recommendations suggest that local excision can be performed safely with promising outcomes in this subset of patients.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Urol Oncol. 2021 Jul 26:S1078-1439(21)00300-8. doi: 10.1016/j.urolonc.2021.06.025. Online ahead of print.ABSTRACTPURPOSE: To investigate the effect of time to prostate-specific antigen (PSA) nadir (TTN) after radiation therapy (RTx) for prostate cancer (PCa) on biochemical recurrence (BCR) and overall survival (OS) rates.PATIENTS AND METHODS: We analyzed 2,506 patients treated with RTx (external beam radiotherapy, brachytherapy or combinations) between years 2000 and 2021. Kaplan Meier and multivariable Cox regression models tested BCR-free survival and OS after stratification according to TTN (≤24 vs. 24.1-60 vs.>60...
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Source Type: research
ConclusionOur translational investigation indicates that the efficacy of TTFields therapy in patients with GBM and GBM cell lines is not affected by the addition of Dex.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Sinead O’Keeffe Phosphorous-doped silica optical fibres with a core diameter of 4 µm were tested in X-ray and proton fields for application in cancer therapy dosimetry. Specifically, the radiation-induced attenuation was investigated in terms of linearity in deposited dose in 15 MV and 6 MV photons and 74 MeV protons, as well as Bragg-peak detection along the proton track. Fibres were found to demonstrate linear relative dose response in both radiation modalities, but possible saturation did occur at the high linear energy transfer of the Bragg peak. This demonstrates the possibility to use these fibres a...
Source: Sensors - Category: Biotechnology Authors: Tags: Communication Source Type: research
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