The importance of the molecular weight of ethyl cellulose on the properties of aqueous-based controlled release coatings
In this study, dispersions of EC with varying viscosity grades (which correspond to molecular weights), ranging from 4 to 100 cps, were produced and characterised. The dispersions showed particle sizes around 200nm and highly negative ζ-potentials (approx. −100mV), which indicated stable dispersions as confirmed by sedimentation studies. The different latexes were used to produce free-standing film coatings. We hypothesised that the different viscosity grades of EC would result in different properties of the films. We found that an increase in viscosity grade (and higher molecular weight) resulted in lower coalescence between the particles during film formation and thus to higher water permeability than in film coatings of lower molecular weight. After exposure to water the EC 4cps and 20cps film coatings had a more porous structure in the side facing the air during production and drying after immersion in water. Molecular weight is therefore a factor that should be considered when producing pharmaceutical coatings for controlled release. Graphical abstract
Chun Peng, Yan-Ling Wang
Øyvind Bruserud, Daniela-Elena Costea, Saila Laakso, Ben-Zion Garty, Eirik Mathisen, Antti Mäkitie, Outi Mäkitie, Eystein S. Husebye
Shirley Telles, Sachin K. Sharma, Niranjan Kala, Sushma Pal, Ram K. Gupta, Acharya Balkrishna
The government needs to take action to stop prescription drugs, including opioids and slimming tablets, being obtained from online pharmacies that can avoid regulation.
Yao-Xin Gao, Hao-Heng Yu, Chuan He, Ming Li, Dan-Dan Guo, Jun-Jiang Lian, Hai-Jie Yang, Mian Wang, Lei Wang, Zhi-Wei Feng, Bin-Feng Cheng
Xuan Xie, Jun Jiang, Wenchu Ye, Ruohong Chen, Yiqun Deng, Jikai Wen
Ning Li, Heng Zhou, Qizhu Tang
Gantumur Battogtokh, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang
Juan F. Garc ía-Henares, Jose A. Moral-Munoz, Alejandro Salazar, Esperanza Del Pozo
Authors: Schaefer A, Lubos E, Pietzsch JB, Pietzsch M, Weber S, Blankenberg S, Reichenspurner H, Schäfer U, Conradi L Abstract AIMS: The German healthcare system was among the first to introduce transcatheter mitral valve repair (TMVR) in routine care. Objective of this study was to analyze adoption and utilization patterns and to estimate impact of TMVR availability on mitral valve (MV) procedure volumes in the first 8 years after commercialization. METHODS AND RESULTS: Procedure volumes were collected from German Federal Statistics Office databases for TMVR and mitral valve surgery (MVS) from 2008-2015. ...