Research team develops new diagnostic tool to identify tinnitus in animals

A behavioral tool has been developed that may significantly aid in understanding the underlying mechanisms of tinnitus, ultimately leading to new drugs and treatment methods, report scientists.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Interview with Christopher R. Cederroth, PhD, author of Association of Genetic vs Environmental Factors in Swedish Adoptees With Clinically Significant Tinnitus
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Source Type: podcasts
This study uses Swedish national registry data to assess the association between genetic vs environmental factors and risk of tinnitus among adoptees.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
Genetic factors are fundamental in the molecular pathologic mechanisms of a number of auditory disorders that present throughout the lifespan. Historically, an understanding of the role of genetics in tinnitus has not been as straightforward because it can be viewed as a symptom of multiple diseases. Risk factors for tinnitus include hearing loss, aging, and noise exposure, most logically connecting its cause with environmental factors. This notion has been supported by a lack of heritability determined from early family-based questionnaire studies. In addition, previous studies that have primarily used genotyping in the p...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
This study used a guinea pig model of hearing loss and tinnitus to investigate effects of low-intensity rTMS (LI-rTMS) over PFC on tinnitus and spontaneous activity in auditory thalamus. In addition, immunohistochemistry for calbindin and parvalbumin in PFC was used to investigate the possible mechanism of action of LI-rTMS. Three treatment groups were compared: sham treatment, LI, low frequency (1 Hz) or LI, high frequency (10 Hz) rTMS (10 min/day, 2 weeks, weekdays only). None of the treatments affected the behavioural measures of tinnitus but spontaneous activity was significantly increased in audito...
Source: Experimental Brain Research - Category: Neuroscience Authors: Tags: Exp Brain Res Source Type: research
Condition:   Tinnitus Intervention:   Other: Physical Therapy Sponsor:   VA Office of Research and Development Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conclusion: Round window niche drilling increases the contact area and time of methylprednisolone. It is an effective and safe salvage therapy of idiopathic SSNHL and its induced tinnitus.Audiol Neurotol 2018;23:309 –315
Source: Audiology and Neurotology - Category: Audiology Source Type: research
Purpose of review Recent enthusiasm for cannabinoid drugs for the treatment of chronic pain and some forms of epilepsy, raises the question of whether they could be useful for other disorders associated with abnormal neuronal activity in the brain, such as subjective tinnitus. Indeed, there is evidence to indicate that some tinnitus sufferers self-medicate using Cannabis. The aim of this review is to critically evaluate the available evidence relating to the effects of cannabinoids on tinnitus. Recent findings Despite the fact that cannabinoids have been shown to decrease neuronal hyperactivity in many parts of the br...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEURO-OTOLOGY: Edited by Thomas Brandt Source Type: research
We report the case of a 42-year-old patient referred for suspicion of fibromuscular dysplasia in the context of a carotid artery dissection occurring after a minor trauma. Initial complaints included left hemicrania, lateral diplopia with left 6th cranial nerve palsy and pulsatile tinnitus. The work-up disclosed a large left carotid-cavernous fistula, as well as more proximal carotid lesions compatible with multifocal fibromuscular dysplasia. Personal history included colonic and uterine perforation. Family history disclosed a fatal hemorrhage due to rupture of a splenic artery aneurysm in the father and an iliac dissectio...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Discussion: Our review has not identified any reliable or reproducible objective measures of tinnitus. However, this piece of work has highlighted emerging areas where further high quality research may lead to the development of an effective method for objectively identifying and measuring the severity of tinnitus.
Source: Otology and Neurotology - Category: ENT & OMF Tags: REVIEW ARTICLES Source Type: research
Conclusions: Transtympanic resurfacing with bone cement, reinforcing the dehiscent JB to reduce focal turbulent flow, is a simple and effective surgical treatment option in patients with PT due to HJBD. In patients with HJBD, the objective measurement of PT by TSR/STA may be of help in selecting appropriate surgical candidates and objective evaluation of the treatment outcome.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
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