Fibrosis: Pericyte MyD88 and IRAK4 signalling in fibrosis

Nature Reviews Nephrology 13, 63 (2017). doi:10.1038/nrneph.2016.174 Author: Susan J. Allison New data suggest that signalling of MyD88 and its downstream effector IRAK4 in pericytes is an important driver of inflammation and fibrogenesis in the injured kidney. Jeremy Duffield and colleagues also show that pharmacological inhibition of IRAK4 signalling suppresses inflammatory and fibrotic markers in kidney
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research