Protein Phosphotyrosine Phosphatase 1B (PTP1B) in Calpain-dependent Feedback Regulation of Vascular Endothelial Growth Factor Receptor (VEGFR2) in Endothelial Cells [Molecular Bases of Disease]

In conclusion, our data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.

Source: Journal of Biological Chemistry - January 12, 2017 Category: Chemistry Authors: Yixuan Zhang, Qiang Li, Ji Youn Youn, Hua Cai Tags: Signal Transduction Source Type: research