Application of Nuclear Magnetic Resonance to Detect Toxigenic Clostridium difficile from Stool Specimens

We evaluated the performance of an early prototype core molecular mirroring nuclear magnetic resonance detection platform (Mentor-100) to detect toxigenic Clostridium difficile from stool. This technology uses customized nanoparticles bound to target specific oligonucleotide probes that form binaries in the presence of nucleic acid from the target microorganism. Liquid patient stool specimens were seeded with C. difficile or other Clostridium species to determine the analytical sensitivity and specificity.

Source: Journal of Molecular Diagnostics - January 8, 2017 Category: Pathology Authors: Paul Yang, Sara Hash, Katherine Park, Charlene Wong, Loganathan Doraisamy, Jonas Petterson, Cathy A. Petti, Pamela M. Ward, Seung H. Lee, Suresh Menon, Rosemary C. She Tags: Technical Advance Source Type: research