Early Cytokine Dysregulation and Viral Replication Are Associated with Mortality During Lethal Influenza Infection

Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - Category: Allergy & Immunology Tags: article Source Type: research

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Lacie Rian Fisher, 15, of Pisgah, North Carolina, died on December 30 after she contracted influenza B, responsible for most pediatric flu deaths this season, which sent her into septic shock.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, mouse pulmonary stem/progenitor cells (mPSCs) with capability to differentiate into type I or type II alveolar cells were used as an in vitro cell model to characterize replication and pathogenic effects of influenza viruses in PSCs. First, mPSCs and its immortalized cell line mPSCsOct4+ were shown to be susceptible to PR8, seasonal H1N1, 2009 pandemic H1N1, and H7N9 influenza viruses and can generate infectious virus particles, although with a lower virus titer, which could be attributed by the reduced vRNA replication and nucleoprotein (NP) aggregation in the cytoplasm. Nevertheless, a significant increase...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 18 January 2020Source: Toxicology ReportsAuthor(s): Afaf M. Weli, Hanady S. Al-Saadi, Rouqaya S. Al-Fudhaili, Amzad Hossain, Zabida Binti Putit, Mahmood K. JasimAbstractMedicinal plant as herbal medicine is widely used to cure infectious diseases. Rubus fruticosus L (R. fruticosus) has been studied for its antimicrobial and cytotoxic activities. Different polarity leave extracts were prepared by using hexane, chloroform, ethyl acetate and hydro alcoholic solvents. Agar diffusion method has been used to assess the antibacterial activity against two gram-positive Enterococcus faecalis and S...
Source: Toxicology Reports - Category: Toxicology Source Type: research
Respiratory tract infections are the second leading cause of mortality and morbidity worldwide1 and community acquired respiratory viruses (CARV) are the most common cause2. This statistic and the recent 2009 H1N1 influenza pandemic have raised awareness in national and transnational health authorities who support developing CARV epidemiological survey systems3 –6. These monitoring activities definitely contribute to health improvement and are extremely useful for national policy makers in identifying groups at high risk and for selecting influenza strains for yearly vaccine production.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Publication date: Available online 17 January 2020Source: Microbes and InfectionAuthor(s): Kazuyuki Mimura, Soichiro Kimura, Chiaki Kajiwara, Sho Nakakubo, Matthew A. Schaller, Yoshikazu Ishii, Theodore J. Standiford, Steven L. Kunkel, Kazuhiro TatedaAbstractPneumococcal conjugate vaccination (PCV) may prevent influenza-related pneumonia, including Streptococcus pneumoniae pneumonia. To investigate PCV efficacy against secondary pneumococcal pneumonia following influenza, PCV was administered intramuscularly 2 and 5 weeks before S. pneumoniae serotype-3 colonization of murine nasopharynges followed by intranasal challenge ...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
(CNN) — That Fitbit you’ve been wearing could be doing a lot more than tracking your trips to the store. It may help health officials stop the flu from spreading, too. Researchers working at the Scripps Research Translational Institute reviewed de-identified data from users wearing Fitbits — the company’s privacy policy allows for the potential use of de-identified user data for research — and found that they were able to do real-time flu prediction at the state level. This marks the first time heart rate trackers and sleep data have been used to predict the flu or any infectious disease in re...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Fitbit Flu Health News Source Type: news
AbstractThe etiologies of undifferentiated fever in pregnant women have not been studied thoroughly. Because of its non-specific presentation but severe prognosis, listeriosis is often suspected in this setting, but in most cases not confirmed. We studied the causes of undifferentiated fever in pregnant women who received preemptive listeriosis treatment. We conducted from November 1, 2011, to June 30, 2013, a prospective multicentric observational cohort study of pregnant women referred to obstetrical wards with undifferentiated fever and who received listeriosis preemptive treatment. Clinical and biological features, tre...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Conditions:   Aspergillosis;   Influenza;   Critical Illness Intervention:   Sponsor:   University Hospital, Brest Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): S. Al Katy, J.P. Stewart, A. Kipar
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): C. Bianco, A. Nunez, P. Sanchez-Cordon, R. Hansen, S. Reid, S. Jeckel, I.H. Brown, S. Thomas, C. Poulos, S.M. Brooks
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
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