GI highlights from the literature

Basic scienceMLKL-mediated hepatocyte necrosis in immune liver disease—not all hepatocyte death is the same Gunther C, He GW, Kremer AE, et al. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest 2016;126:4346–60. Hepatocellular death has long been associated with both acute and chronic liver injury. Mechanisms of cell death can extend beyond apoptosis and necrosis and vary greatly, with pathways such as necroptosis (programmed cell necrosis) now well described. A more detailed dissection of the pathways involved in hepatocellular death in different modes of liver injury may yield new insights into disease pathogenesis. In this article, the authors describe a novel mixed lineage kinase domain-like protein (MLKL)-dependent programmed hepatocyte necrosis pathway, which may have relevance for the pathogenesis of immune-mediated liver diseases. In the context of necroptosis, receptor interacting protein kinase 3 (RIPK3) results in the activation of MLKL, which...
Source: Gut - Category: Gastroenterology Authors: Tags: JournalScan Source Type: research