Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance

This study suggests important consequences for clinical castration resistance due to simultaneous expression of AR-FL and AR-Vs in patient tumors and suggests that dissecting these interactions should help develop effective strategies to disrupt AR-V signaling. Mol Cancer Res; 15(1); 59–68. ©2016 AACR.

Source: Molecular Cancer Research - January 2, 2017 Category: Cancer & Oncology Authors: Zhan, Y., Zhang, G., Wang, X., Qi, Y., Bai, S., Li, D., Ma, T., Sartor, O., Flemington, E. K., Zhang, H., Lee, P., Dong, Y. Tags: Signal Transduction Source Type: research