Leukocyte Adhesion Deficiency III: Report of Two Siblings

Leukocyte adhesion deficiencies (LADs) are autosomal recessive immunodeficiency disorders characterized by a blockage in the process of leukocyte emigration to sites of inflammation.1 There are three types of this disease, each affecting a different phase of the leukocyte adhesion cycle. LAD III is caused by a defect in leukocyte integrin activation due to a mutation in the FERMT3 gene.2 The structure and expression of an integrin expression level in LAD III is normal in contrast to that in LAD I.

Source: Pediatrics and Neonatology - December 30, 2016 Category: Perinatology & Neonatology Authors: Deniz Aygun, Serdar Nepesov, Ruth Gershoni, Y ıldız Camcıoglu Tags: Letter to the Editor Source Type: research