The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes

Conclusions:
This architecture, its dynamics, and accessibility, balance stability and flexibility ensuring genome integrity and variation enabling gene expression/regulation by self-organization of (in)active units already in proximity. Our results agree with the heuristics of the field and allow “ architectural sequencing ” at a genome mechanics level to understand the inseparable systems genomic properties.

Source: International Journal of Pediatric Endocrinology - December 23, 2016 Category: Endocrinology Authors: Tobias Knoch Malte Wachsmuth Nick Kepper Michael Lesnussa Anis Abuseiris A. Ali Imam Petros Kolovos Jessica Zuin Christel Kockx Rutger Brouwer Harmen van de Werken Wilfred van IJcken Kerstin Wendt Frank Grosveld Source Type: research