4 steps to high-quality 3D printing for radiology
3D printing has skyrocketed in popularity in recent years with the advent of...Read more on AuntMinnie.comRelated Reading: 3D-printed kidney phantom advances SPECT/CT calibration 3D-printed models are accurate for complex lung cancers Dubai hospitals to implement 3D printing before surgery Center refines 3D printing to build 'replacement parts' 3D printing finds myriad roles in healthcare
Authors: Mavriopoulou E, Zampakis P, Smpiliri E, Spyridonidis T, Rapti E, Haberkorn U, Makatsoris T, Apostolopoulos DJ Abstract OBJECTIVE: Single photon emission tomography/computed tomography (SPET/CT) is usually recommended after ambiguous whole body bone scan (WBS) findings. We investigated the value of routine 2-field ("near" whole-body) SPET/CT application in breast cancer (BC) patients. SUBJECTS AND METHODS: In this prospective study planar WBS and 2-field SPET/CT was performed in 257 consecutive BC patients referred for a bone scan. Whole body scan and SPET/CT were interpreted separately. Addit...
CONCLUSION: Our findings suggested that 99mTc WBS is a useful imaging modality in detecting remnant thyroid tissue, nodal and distant metastases before 131I therapy. The additional SPET/CT scan when needed in 18 cases supported the 99mTc WBS diagnosis. PMID: 30089313 [PubMed - in process]
Because of the rich lymphatic network in the head and neck region, there is a long-standing convention to electively irradiate the great majority of patients with head and neck squamous cell carcinoma (HNSCC) to both sides of the neck in order to reduce the risk of contralateral regional failure (cRF). For example, of 620 patients with HNSCC treated at our institution with (chemo)radiotherapy between 2009 and 2016 who had an indication for elective nodal irradiation (ENI), only 43 patients (7%) were treated to one side of the neck (data not published).
CONCLUSIONS: Selective SPECT/CT-guided ENI results in significant dose reductions to various organs-at-risk and corresponding NTCP values, and will subsequently reduce the incidence and severity of different troublesome radiation-related toxicities and improve quality-of-life. PMID: 30087057 [PubMed - as supplied by publisher]
AbstractRadiotheragnostics represents the systematic integration of diagnostic imaging and therapeutics using radionuclides targeting specific characteristics of tumor biology. Radioiodine (131I) is the classic radiotheragnostic agent used for the diagnosis and treatment of differentiated thyroid cancer based on sodium-iodine symporter expression in normal and neoplastic thyroid tissue. Application of radiotheragnostics principles in thyroid cancer involves using pre-ablation diagnostic scans (Dx Scans) for detection of iodine-avid regional and distant metastatic disease and patient-individualized targeted131I therapy with...
ConclusionFor both Lu-177-Octreotate and Lu-177-PSMA-617 therapy, BM dosimetry via sequential QSPECT imaging and a single WB-P acquisition is feasible, if this WB-P image is acquired at a late time point (48 or 72 h post-injection). The reliability of the HP can be well accepted considering the uncertainties of quantitative Lu-177 imaging and BM dosimetry using standardised organ-levelS values.
CONCLUSION: Functional lung imaging may have potential utility in radiation therapy planning and delivery, although significant heterogeneity was identified in approaches and reporting. Recommendations have been made based on the available evidence for future functional lung trials. PMID: 30082143 [PubMed - as supplied by publisher]
Conclusion: Radiolabeled 16F12 could represent a new theranostic tool for small-volume ovarian peritoneal carcinomatosis. Specifically, 213Bi-16F12–based BIP-RIT could be proposed to selected patients as an alternative adjuvant treatment immediately after cytoreductive surgery. An anti-MISRII mAb is currently being used in a first-in-human study, thus making radiolabeled anti-MISRII mAbs a realistic theranostic option for the clinic.
ConclusionsOverall the DROP-IN design proves to be a valuable tool for robot-assisted radioguided surgery approaches.
ConclusionSPECT/CT-guided LDM is feasible and can be used to guide unilateral ENI in HNSCC patients in prospective studies. In addition, the anatomical confidence in visualization of contralateral drainage indicates a potential for ENI limited to draining levels alone.