Nucleic acid-sensing TLRs: trafficking and regulation.

Nucleic acid-sensing TLRs: trafficking and regulation.
Curr Opin Immunol. 2016 Nov 28;44:26-33
Authors: Majer O, Liu B, Barton GM
Abstract
Toll-like receptors (TLRs) play an important role in innate immune responses against pathogenic microorganisms or tissue damage. Nucleic acid (NA)-sensing TLRs localize in intracellular vesicular compartments and recognize foreign-derived and host-derived nucleic acid ligands. Inappropriate activation of NA-sensing TLRs can cause pathogenic inflammation and autoimmunity. Multiple regulatory mechanisms exist to limit recognition of self-NAs. This review summarizes recent progress that has been made in understanding how NA-sensing TLRs are regulated via trafficking, proteolytic cleavage, as well as ligand processing and recognition.
PMID: 27907816 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - November 27, 2016 Category: Allergy & Immunology Authors: Majer O, Liu B, Barton GM Tags: Curr Opin Immunol Source Type: research