Rhamnocitrin glycosides from Oxytropis chiliophylla

Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jun Wang, Yang Liu, Norbo Kelsang, Kewu Zeng, Hong Liang, Qingying Zhang, Pengfei Tu Repeated chromatography of the n-BuOH soluble fraction from ethanol extract of the aerial part of Oxytropis chiliophylla led to the isolation of six new rhamnocitrin glycosides, named oxychilioflavonosides A−F (1–6), together with eight known rhamnocitrin glycosides (7–14) of which six were isolated from the genus Oxytropis for the first time. The structures of these compounds were elucidated by extensive spectroscopic techniques and chemical methods. All isolated compounds were evaluated for their anti-inflammatory activity in lipopolysaccharide (LPS)-induced BV-2 microglial cells, and compound 11 showed potent inhibition on NO production with IC50 value of 9.91μM. Graphical abstract

Source: Phytochemistry Letters - November 29, 2016 Category: Chemistry Source Type: research