Longer Preservation Time Doesn't Harm Lungs for Transplant Longer Preservation Time Doesn't Harm Lungs for Transplant

Extending overall preservation time via ex-vivo lung perfusion (EVLP) appears to have no negative impact on short-term outcomes of lung transplantation, according to Canadian and Swiss investigators.Reuters Health Information
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Transplantation News Source Type: news

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In this study we describe 2 cases of successful adult DCD HT performed at our institution using an original protocol.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Featured papers Source Type: research
Abstract PURPOSE OF REVIEW: Within the last decade, ex-vivo lung perfusion (EVLP) has become a widespread technology used for organ assessment and reconditioning within clinical transplantation. This review aims to offer insights toward future applications and developments in regards to its utility. RECENT FINDINGS: The intervention of EVLP is a well-tolerated method to effectively allow for extended preservation periods. The thoughtful usage of EVLP can therefore be used to optimize operating room logistics and progress lung transplantation toward becoming a more elective procedure. EVLP has also demonstrate...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Abstract PURPOSE OF REVIEW: The current review presents a concise update on published literature on donation after circulatory death (DCD) and lung transplantation (LTx). Worldwide an increasing need for lungs is evident, however the utilization rate of DCD lung donors is still considerably low. In this summary article, we reviewed both the experimental background and international clinical experience. RECENT FINDINGS: Our analysis confirmed satisfactory results for LTx from DCD donors, which equals the results from donation after brain death. Although most studies reported on short-term results, some confirm...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Purpose of review The current review presents a concise update on published literature on donation after circulatory death (DCD) and lung transplantation (LTx). Worldwide an increasing need for lungs is evident, however the utilization rate of DCD lung donors is still considerably low. In this summary article, we reviewed both the experimental background and international clinical experience. Recent findings Our analysis confirmed satisfactory results for LTx from DCD donors, which equals the results from donation after brain death. Although most studies reported on short-term results, some confirmed these results on ...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: LUNG TRANSPLANTATION: Edited by Allan R. Glanville Source Type: research
Purpose of review Within the last decade, ex-vivo lung perfusion (EVLP) has become a widespread technology used for organ assessment and reconditioning within clinical transplantation. This review aims to offer insights toward future applications and developments in regards to its utility. Recent findings The intervention of EVLP is a well-tolerated method to effectively allow for extended preservation periods. The thoughtful usage of EVLP can therefore be used to optimize operating room logistics and progress lung transplantation toward becoming a more elective procedure. EVLP has also demonstrated itself as an excel...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: LUNG TRANSPLANTATION: Edited by Allan R. Glanville Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
ConclusionAlthough LT is feasible for patients with HPS, early transplantation and avoiding hypo ‐oxygenemia immediately after transplantation are important.This article is protected by copyright. All rights reserved.
Source: Journal of Hepato-Biliary-Pancreatic Surgery - Category: Surgery Authors: Tags: Original Article Source Type: research
XVIVO Perfusion, a company based out in Göteborg, Sweden, has been approved to introduce its Xvivo Perfusion System in the United States to effectively renew lungs that would otherwise would not be good enough for transplantation. The system ven...
Source: Medgadget - Category: Medical Devices Authors: Tags: Cardiac Surgery Source Type: blogs
Conclusions. Continuous administration of clopidogrel significantly improved tissue oxygenation, limited microvascular leakiness, and prevented airway ischemia. These data demonstrate that clopidogrel ameliorates microvascular injury during acute airway rejection, which is a known predisposing factor for the development of CLAD.
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Conclusions In both mouse and human, uNK cells are the most prominent immune cells that occupy the maternal-fetal interface. The uNK cells appear to engage and establish complex interactions with the surrounding tissue, which impact their function. As more cell subsets are identified within the heterogeneous uNK cell population, it is anticipated that their functional heterogeneity will extend beyond vascular modification, growth-promotion and memory generation. Author Contributions DS wrote the manuscript. LY provided the micrographs and WY edited the manuscript. Funding Work in the Yokoyama lab on uterine NK cells i...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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