A highly polar phytocomplex involving rutin is responsible for the neuromuscular facilitation caused by Casearia sylvestris (gua çatonga).

CONCLUSION: F55-6 apparently caused neurofacilitation by the same mechanism (presynaptic action) as the methanolic fraction since its activity was also inhibited in tetrodotoxin-pretreated preparations.
PMID: 27855599 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Biotechnology - November 16, 2016 Category: Biotechnology Authors: Eh Y, N T, Al F, Ca F, Rvs T, Tj B, Pcp B, Aj C, S H, P P, A SF, Y OF Tags: Curr Pharm Biotechnol Source Type: research