Persistence of Antibodies Against MERS Coronavirus Persistence of Antibodies Against MERS Coronavirus
How long are antibodies against MERS-CoV detectable after symptomatic infection?Emerging Infectious Diseases
From 1 January through 31 January 2019, the International Health Regulations (IHR) National Focal Point of Saudi Arabia reported fourteen additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including three deaths.
Abstract We evaluated genetic variation in Middle East respiratory syndrome coronavirus (MERS-CoV) imported to South Korea in 2018 using specimens from a patient and isolates from infected Caco-2 cells. The MERS-CoV strain in this study was genetically similar to a strain isolated in Riyadh, Saudi Arabia, in 2017. PMID: 30753126 [PubMed - as supplied by publisher]
ram Misra Insectivorous bats are speculated to be ancestral hosts of Middle-East respiratory syndrome (MERS) coronavirus (CoV). MERS-CoV causes disease in humans with thirty-five percent fatality, and has evolved proteins that counteract human antiviral responses. Since bats experimentally infected with MERS-CoV do not develop signs of disease, we tested the hypothesis that MERS-CoV would replicate less efficiently in bat cells than in human cells because of its inability to subvert antiviral responses in bat cells. We infected human and bat (Eptesicus fuscus) cells with MERS-CoV and observed that the virus grew to hig...
Y. Chung et al.
From 27 January and 31 January 2019, the International Health Regulations (IHR) National Focal Point of Oman reported five cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection.
Publication date: Available online 31 January 2019Source: CellAuthor(s): Alexandra C. Walls, Xiaoli Xiong, Young-Jun Park, M. Alejandra Tortorici, Joost Snijder, Joel Quispe, Elisabetta Cameroni, Robin Gopal, Mian Dai, Antonio Lanzavecchia, Maria Zambon, Félix A. Rey, Davide Corti, David VeeslerSummaryRecent outbreaks of severe acute respiratory syndrome and Middle East respiratory syndrome, along with the threat of a future coronavirus-mediated pandemic, underscore the importance of finding ways to combat these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and is the m...
Purpose: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) remains an emerging disease threat, with regular reports of human cases on the Arabian Peninsula, driven by recurring camel-to-human transmission events. A prophylactic vaccine under development has been found to greatly reduce shedding in dromedaries, but there are major gaps in our quantitative understanding of the epidemiology of MERS-CoV in dromedary populations. The purpose of our work is to develop a mathematical model of MERS-CoV transmission in camels in order to address these gaps and to eventually inform the development of evidence-based animal vaccination strategies.
Purpose: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a highly pathogenic zoonosis that emerged in 2012, causing lethal respiratory disease in approximately 35% of human cases. MERS-CoV continues to emerge on the Arabian Peninsula with the possibility of travel-exported cases to other regions of the world including prior confirmed cases in the Republic of Korea, the United States, England, France, and China. Currently, there are no specific countermeasures for MERS-CoV that have proven efficacious at ameliorating disease.
Purpose: Out of more than 2400 patients with severe acute respiratory infections who travelled to the Philippines from the Middle East since 2013, only two cases were confirmed positive for the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Considering that these respiratory infections were imported into the country, it is important to determine the pathogen/s causing the disease to mitigate potential outbreaks that may overburden the country's health care system.
Purpose: Coronaviruses are RNA viruses encompassing four genera. The alpha- and betacoronaviruses commonly cause mild disease in humans. However, outbreaks of severe respiratory disease in 2002 and 2012 led to the identification of highly pathogenic human betacoronaviruses, SARS- and MERS-CoV, respectively. Bats are believed to be the reservoir host from which all mammalian coronaviruses emerged.